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Art. -Nr.: HY-184107

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Bcl-2-IN-25

Bcl-2-IN-25 is an orally active Bcl-2 inhibitor that induces cytotoxic activity in cancer cells. Bcl-2-IN-25 can be used in cancer-related research.

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CAS. Nr.: 2290611-27-5
Formel: C₄₇H₅₃ClN₈O₈S
Molecular Weight:925.49

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Bcl-2-IN-25 Chemical Structure

CAS. Nr.: 2290611-27-5

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- Parmacokinetics
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Bcl-2-IN-25 is an orally active Bcl-2 inhibitor that induces cytotoxic activity in cancer cells. Bcl-2-IN-25 can be used in cancer-related research^[1].

IC₅₀ & Target^[1]

Bcl-2

Alle Bcl-2 Family Isoform-spezifische Produkte anzeigen :

In Vitro

Bcl-2-IN-25 (Example 9) inhibits viability of human small cell lung carcinoma H146, H889, and H1963 cells with IC₅₀ values of 33 nM, 0.7 nM, and 4.7 nM, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Parmacokinetics

Species	Dose	Route	AUC_last	T_1/2	Bioavailability
Mice^[1]	10 mg/kg	p.o.	8168 ng·h/mL	2.3 h	64 %

In Vivo

Bcl-2-IN-25 (Example 9) (10 mg/kg; single oral gavage administration) exhibits favorable pharmacokinetic profiles in CD-1 mice, with an area under the curve AUC_LAST = 8168 h*ng/mL, an elimination half-life t_1/2 = 2.3 h, and an oral bioavailability of 64%.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 2290611-27-5
Molecular Weight 925.49
Formel C₄₇H₅₃ClN₈O₈S
SMILES

O=S(NC(C1=C(C=C(N2CCN(CC2)CC3=C(C4=CC=C(C=C4)Cl)CC(C)(CC3)C)C=C1)N5C6=C(OCCC5)NC7=NC=CC7=C6)=O)(C8=CC([N+]([O-])=O)=C(C=C8)NC[C@H]9COCCO9)=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Chen Y. Condensed heterocyclic derivatives as bcl-2 inhibitors for the treatment of neoplastic diseases. WO2019040550A1. WIPO; 2019 Feb 28.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise

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Bcl-2-IN-25

Alle Bcl-2 Family Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

Bcl-2-IN-25 Related Classifications

HY-184107 Related Classifications