country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Art. -Nr.: HY-12807A

Copy Link Print Information

FIPI hydrochloride

(Synonyms: 5-Fluoro-2-indolyl deschlorohalopemide hydrochloride)

5 Cited Publications

Kundenbewertung

Based on 5 publication(s) in Google Scholar

FIPI hydrochloride is a phospholipase D (PLD) inhibitor with an IC₅₀ for PLD1 and PLD2 of about 25 nM. FIPI hydrochloride regulates cytoskeletal recombination, cell diffusion and chemotaxis. FIPI hydrochloride can be used in cancer research. In addition, FIPI hydrochloride can enhance the secretion and aggregation of platelet dense particles, inhibit thrombosis, reduce ischemic stroke infarct volume and improve nerve function.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 1781834-93-2
Formel: C₂₃H₂₅ClFN₅O₂
Molecular Weight:457.93

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

FIPI hydrochloride Chemical Structure

CAS. Nr.: 1781834-93-2

Größe

Preis

Verfügbarkeit

Menge

Amount: USD 0.00

* Bitte wählen Sie Menge, bevor Sie Artikel hinzufügen.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
Chemical Information
Publications (5)
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target^[1]

PLD1

PLD2

Alle Phospholipase Isoform-spezifische Produkte anzeigen :

Chemical Information

CAS. Nr. 1781834-93-2
Molecular Weight 457.93
Formel C₂₃H₂₅ClFN₅O₂
SMILES

O=C(NCCN1CCC(CC1)N2C3=CC=CC=C3NC2=O)C4=CC5=C(C=CC(F)=C5)N4.[H]Cl
Synonyms

5-Fluoro-2-indolyl deschlorohalopemide hydrochloride
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (5)

All Cell Proliferation/Viability AssayCell Migration/Invasion AssayWBIF

Sort by:

Journal Impact Factor

Anal Chem

Phospholipid-Tailored Titanium Carbide Nanosheets as a Novel Fluorescent Nanoprobe for Activity Assay and Imaging of Phospholipase D. [Abstract]

2018 Jun 5;90(11):6742-6748. PMID: 29737155

FIPI hydrochloride purchased from MedChemExpress. Usage Cited in: Anal Chem. 2018 Jun 5;90(11):6742-6748. [Abstract]

Typical CSLM images of MDA-MB-231 cells incubated with 50 μg/mL RhB-PL-Ti₃C₂ for 4 h at 37°C in the absence (I) and presence of 1.0 mg/mL FIPI (II), and CSLM images of MCF-7 cells (III) incubated with 50 μg/mL RhB-PL-Ti₃C₂ for 4 h at 37°C.
Biochem Pharmacol

Phospholipase D2 regulation by transcription factor FOXA1 promotes the drug resistance of vemurafenib in melanoma cells. [Abstract]

2025 Dec;242(Pt 4):117434. PMID: 41110487
J Cell Sci

The protein kinase D1-mediated classical protein secretory pathway regulates the Ras oncogene-induced senescence response. [Abstract]

2018 Mar 16;131(6). pii: jcs207217. PMID: 29420297

FIPI hydrochloride purchased from MedChemExpress. Usage Cited in: J Cell Sci. 2018 Mar 16;131(6). pii: jcs207217. [Abstract]

ER:Ras IMR90 cells are treated with solvent or FIPI (250 nM, 2h).Western blotting are performed.
Patent

US20230050888A1.
Nanoscale Res Lett

Preparation and Evaluation of Liposomes Co-Loaded with Doxorubicin, Phospholipase D Inhibitor 5-Fluoro-2-Indolyl Deschlorohalopemide (FIPI) and D-Alpha Tocopheryl Acid Succinate (α-TOS) for Anti-Metastasis. [Abstract]

2019 Apr 18;14(1):138. PMID: 31001703

FIPI hydrochloride purchased from MedChemExpress. Usage Cited in: Nanoscale Res Lett. 2019 Apr 18;14(1):138. [Abstract]

Cell viability of MDA-MB-231 cells incubated with Blank-lip, FIPI-lip, DF-lip, DT-lip, and DFT-lip for 7 h or 24 h at a concentration of 2 μM FIPI, respectively.

FIPI hydrochloride purchased from MedChemExpress. Usage Cited in: Nanoscale Res Lett. 2019 Apr 18;14(1):138. [Abstract]

Inhibition effects on the cell motility in vitro. Images of MDA-MB-231 cells wound edge after incubation with control, Blank-lip, FIPI-lip, DF-lip, DT-lip, and DFT-lip for 48 h, respectively (magnification, × 100).

FIPI hydrochloride purchased from MedChemExpress. Usage Cited in: Nanoscale Res Lett. 2019 Apr 18;14(1):138. [Abstract]

Inhibition effects on cell migration. Images of MDA-MB-231 cell migration after incubation with control, Blank-lip, FIPI-lip, DF-lip, DT-lip, and DFT-lip for 7 h at a concentration of 2 μM FIPI.

FIPI hydrochloride purchased from MedChemExpress. Usage Cited in: Nanoscale Res Lett. 2019 Apr 18;14(1):138. [Abstract]

Inhibition effects on the cell invasion. Images of MDA-MB-231 cell invasion after incubation with control, Blank-lip, FIPI-lip, DF-lip, DT-lip, and DFT-lip for 24 h a concentration of 2 μM FIPI (magnification, × 100).

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Su W, et al. 5-Fluoro-2-indolyl des-chlorohalopemide (FIPI), a phospholipase D pharmacological inhibitor that alters cell spreading and inhibits chemotaxis. Mol Pharmacol. 2009 Mar;75(3):437-46. [Content Brief]

[2]. Monovich L, et al. Optimization of halopemide for phospholipase D2 inhibition. Bioorg Med Chem Lett. 2007 Apr 15;17(8):2310-1. [Content Brief]

[3]. Claudia Dall'Armi, et al. The phospholipase D1 pathway modulates macroautophagy. Nat Commun. 2010:1:142. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

FIPI hydrochloride

5 Cited Publications

100 mg Angebot einholen

Subscribe to the

MedChemExpress

Newsletter

MOQ

Minimum order quantity

100 mg

Angebot einholen Auf Lager

Other size

Angebot einholen

Amount: USD 0.00

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
Chemical Information
Publications (5)
Reinheit & Dokumentation
Verweise

1/16
1/16

FIPI hydrochloride purchased from MedChemExpress. Usage Cited in: Nanoscale Res Lett. 2019 Apr 18;14(1):138. [Abstract]

Customer Validation
Cell viability of MDA-MB-231 cells incubated with Blank-lip, FIPI-lip, DF-lip, DT-lip, and DFT-lip for 7 h or 24 h at a concentration of 2 μM FIPI, respectively.
1/16

FIPI hydrochloride purchased from MedChemExpress. Usage Cited in: Nanoscale Res Lett. 2019 Apr 18;14(1):138. [Abstract]

Customer Validation
Inhibition effects on the cell motility in vitro. Images of MDA-MB-231 cells wound edge after incubation with control, Blank-lip, FIPI-lip, DF-lip, DT-lip, and DFT-lip for 48 h, respectively (magnification, × 100).
1/16

FIPI hydrochloride purchased from MedChemExpress. Usage Cited in: Nanoscale Res Lett. 2019 Apr 18;14(1):138. [Abstract]

Customer Validation
Inhibition effects on cell migration. Images of MDA-MB-231 cell migration after incubation with control, Blank-lip, FIPI-lip, DF-lip, DT-lip, and DFT-lip for 7 h at a concentration of 2 μM FIPI.
1/16

FIPI hydrochloride purchased from MedChemExpress. Usage Cited in: Nanoscale Res Lett. 2019 Apr 18;14(1):138. [Abstract]

Customer Validation
Inhibition effects on the cell invasion. Images of MDA-MB-231 cell invasion after incubation with control, Blank-lip, FIPI-lip, DF-lip, DT-lip, and DFT-lip for 24 h a concentration of 2 μM FIPI (magnification, × 100).
1/16

FIPI hydrochloride purchased from MedChemExpress. Usage Cited in: Anal Chem. 2018 Jun 5;90(11):6742-6748. [Abstract]

Customer Validation
Typical CSLM images of MDA-MB-231 cells incubated with 50 μg/mL RhB-PL-Ti₃C₂ for 4 h at 37°C in the absence (I) and presence of 1.0 mg/mL FIPI (II), and CSLM images of MCF-7 cells (III) incubated with 50 μg/mL RhB-PL-Ti₃C₂ for 4 h at 37°C.
1/16

FIPI hydrochloride purchased from MedChemExpress. Usage Cited in: J Cell Sci. 2018 Mar 16;131(6). pii: jcs207217. [Abstract]

Customer Validation
ER:Ras IMR90 cells are treated with solvent or FIPI (250 nM, 2h).Western blotting are performed.

Produktname:
Art. -Nr.:
Menge:
MCE Japan Authorized Agent:

Produktname:
CAS. Nr.:
Species:
Reinheit:
Menge:

FIPI hydrochloride

Publications Citing Use of MedChemExpress (MCE) FIPI hydrochloride

Alle Phospholipase Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Publications (5)

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

FIPI hydrochloride Related Classifications

HY-12807A Related Classifications