Pde2a - phosphodiesterase 2A, cGMP-stimulated Gene

Also Known as cGSPDE; CGS-PDE

Species: Mus musculus

Gene Type: protein coding
Gene ID: 207728

About Pde2a

Chromosome 7: 101,060,093-101,162,026 forward strand.GRCm39:CM001000.3

This gene has 1 transcript (splice variant). Broad expression in adrenal adult (RPKM 43.4), cortex adult (RPKM 43.1) and 24 other tissues.

Summary

Enables several functions, including 3',5'-cyclic-nucleotide phosphodiesterase activity; GAF domain binding activity; and cyclic nucleotide binding activity. Involved in several processes, including cGMP catabolic process; cyclic-nucleotide-mediated signaling; and negative regulation of intracellular signal transduction. Acts upstream of or within cellular response to lipopolysaccharide; circulatory system development; and regulation of nitric oxide mediated signal transduction. Located in several cellular components, including mitochondrion; perinuclear region of cytoplasm; and presynaptic membrane. Is expressed in several structures, including genitourinary system; gut; hemolymphoid system; nervous system; and sensory organ. Orthologous to human PDE2A (phosphodiesterase 2A). [provided by Alliance of Genome Resources, Apr 2022]

Pde2a Products (5)

mRNA Protein Name
NM_001008548.5 NP_001008548.1 cGMP-dependent 3',5'-cyclic phosphodiesterase isoform PDE2A3
NM_001143848.3 NP_001137320.1 cGMP-dependent 3',5'-cyclic phosphodiesterase isoform 6
NM_001243757.2 NP_001230686.1 cGMP-dependent 3',5'-cyclic phosphodiesterase isoform PDE2A1
NM_001143849.3 NP_001137321.1 cGMP-dependent 3',5'-cyclic phosphodiesterase isoform PDE2A2 precursor
NM_001243758.2 NP_001230687.1 cGMP-dependent 3',5'-cyclic phosphodiesterase isoform 5

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables 3',5'-cGMP-stimulated cyclic-nucleotide phosphodiesterase activity IDA
IDA: Inferred from direct assay
15210692 MGI
enables 3',5'-cyclic-AMP phosphodiesterase activity IMP
IMP: Inferred from mutant phenotype
21724846 MGI
enables 3',5'-cyclic-GMP phosphodiesterase activity IMP
IMP: Inferred from mutant phenotype
21724846 MGI
enables GAF domain binding IDA
IDA: Inferred from direct assay
12271124 MGI
enables cAMP binding IMP
IMP: Inferred from mutant phenotype
15210692 MGI
enables cGMP binding IDA
IDA: Inferred from direct assay
12271124 MGI
enables cGMP binding IMP
IMP: Inferred from mutant phenotype
15210692 MGI
enables protein homodimerization activity IDA
IDA: Inferred from direct assay
12271124 MGI
Biological Process GO Annotation Evidence Verweise Source
acts upstream of or within aorta development IMP
IMP: Inferred from mutant phenotype
25807483 MGI
involved in cAMP-mediated signaling IDA
IDA: Inferred from direct assay
15210692 MGI
involved in cGMP catabolic process IMP
IMP: Inferred from mutant phenotype
19632989 MGI
involved in cGMP-mediated signaling IDA
IDA: Inferred from direct assay
15210692 MGI
acts upstream of or within cardiac septum development IMP
IMP: Inferred from mutant phenotype
25807483 MGI
involved in cellular response to lipopolysaccharide IEP
IEP: Inferred from expression pattern
21571906 MGI
involved in cellular response to mechanical stimulus IDA
IDA: Inferred from direct assay
21571906 MGI
acts upstream of or within coronary vasculature development IMP
IMP: Inferred from mutant phenotype
25807483 MGI
acts upstream of or within heart development IMP
IMP: Inferred from mutant phenotype
25807483 MGI
acts upstream of or within heart valve development IMP
IMP: Inferred from mutant phenotype
25807483 MGI
involved in intracellular signal transduction IMP
IMP: Inferred from mutant phenotype
28463107 MGI
involved in negative regulation of cAMP-mediated signaling IMP
IMP: Inferred from mutant phenotype
21571906 MGI
involved in negative regulation of cGMP-mediated signaling IMP
IMP: Inferred from mutant phenotype
21724846 MGI
involved in negative regulation of oxidative phosphorylation IMP
IMP: Inferred from mutant phenotype
21724846 MGI
involved in positive regulation of gene expression IMP
IMP: Inferred from mutant phenotype
21571906 MGI
involved in positive regulation of inflammatory response IMP
IMP: Inferred from mutant phenotype
21571906 MGI
involved in regulation of mitochondrion organization IMP
IMP: Inferred from mutant phenotype
28463107 MGI
acts upstream of or within regulation of nitric oxide mediated signal transduction IGI
IGI: Inferred from genetic interaction
16150726 MGI
acts upstream of or within ventricular septum development IMP
IMP: Inferred from mutant phenotype
25807483 MGI
Cellular Component GO Annotation Evidence Verweise Source
located in Golgi apparatus IDA
IDA: Inferred from direct assay
19632989 MGI
located in axon IDA
IDA: Inferred from direct assay
8586960 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
19506089 MGI
located in cytosol IDA
IDA: Inferred from direct assay
17329248 MGI
located in dendrite IDA
IDA: Inferred from direct assay
8586960 MGI
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
19632989 MGI
located in mitochondrial inner membrane IDA
IDA: Inferred from direct assay
28463107 MGI
located in mitochondrial matrix IDA
IDA: Inferred from direct assay
21724846 MGI
located in mitochondrial outer membrane IDA
IDA: Inferred from direct assay
28463107 MGI
located in mitochondrion IDA
IDA: Inferred from direct assay
28463107 MGI
located in nucleus IDA
IDA: Inferred from direct assay
19632989 MGI
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
19632989 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
19632989 MGI
located in presynaptic membrane IDA
IDA: Inferred from direct assay
19506089 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Pde2a Protein Structure

GAF

GAF: smart00065 (234 - 385)

GAF

GAF: smart00065 (407 - 556)

PDEase_I

PDEase_I: pfam00233 (653 - 886)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 939 a.a.
Protein Preferred Names Protein Names

cGMP-dependent 3',5'-cyclic phosphodiesterase

  • cyclic GMP-stimulated phosphodiesterase

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (4)
Art. -Nr. Produktname Wirkung
Reinheit Phase
HY-112831 Osoresnontrine Inhibitor 99.94% Phase 2
HY-111167 AN-2898 Inhibitor / Phase 2
HY-111371 PF-05180999 Inhibitor 99.96% Phase 1
HY-103493 TAK-915 Inhibitor 99.57% Phase 1

Pre-clinical Phase

Bioactive Molecules (13)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-102050 PF-05085727 Inhibitor 99.53% Unkown
HY-132993 Hcyb1 Inhibitor 98.20% Unkown
HY-U00427 PDE2A-IN-3 Inhibitor 99.88% Unkown
HY-102043 PDM-631 Inhibitor / Unkown
HY-112704 PDE5-IN-2 Inhibitor / Unkown
HY-120710 DNS-8254 Inhibitor / Unkown
HY-142660 PDE2A-IN-1 Inhibitor / Unkown
HY-168966 JNJ-54082730 / Unkown
HY-180526 PDE2A-IN-2 Inhibitor / Unkown
HY-RS10213 PDE2A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10214 Pde2a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10215 Pde2a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-124173 PF-06815189 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pde2a NCBI NCBI:5138