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Cat. No.: HY-180526

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PDE2A-IN-2

PDE2A-IN-2 is a selective and brain-penetrant PDE2A inhibitor (K_i = 5.49 nM and 100 > fold selectivity over other PDE isoforms). The ¹¹C-labeled PDE2A-IN-2 serves as a positron emission tomography (PET) tracer for brain imaging in patients with neurodegenerative diseases. PDE2A-IN-2 educes the radiotracer signal in PDE2A-rich regions in vitro. PDE2A-IN-2 exhibits low binding affinity in vivo. PDE2A-IN-2 can be used for neurodegenerative diseases .

For research use only. We do not sell to patients.

CAS No.: 2055901-03-4
Formula: C₁₇H₁₆F₃N₅
Molecular Weight:347.34

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

PDE2A-IN-2 Chemical Structure

CAS No.: 2055901-03-4

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

PDE2A

5.49 nM (Ki)

All Phosphodiesterase (PDE) Isoforms :

In Vitro

PDE2A-IN-2 (compound 1) (1 μM, 30 min) reduces the radiotracer signal in PDE2A-rich regions, leading to a more homogeneous distribution in SD rat brain sections when co-treated with its unlabeled form (1 μM) ^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

PDE2A-IN-2 (compound 1) (1 mg/kg, i.v., once) exhibits low binding affinity in SD rat^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

SD rat^[1]
Dosage:

1 mg/kg
Administration:

i.v., once
Result:

Led to similar TAC patterns and regional brain distributions to baseline.

Chemical Information

CAS No. 2055901-03-4
Molecular Weight 347.34
Formula C₁₇H₁₆F₃N₅
SMILES

CC1=NC2=C(C(NC3(C4=CC=C(C=C4)C(F)(F)F)CC3)=N1)C=NN2C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Li Y, et al. Radiosynthesis and Preclinical Evaluation of a Novel 11C Labeled Pyrazolopyrimidine Derivative for Positron Emission Tomography Imaging of Phosphodiesterase 2A. ACS Med Chem Lett. 2025 Dec 12;17(1):218-225. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References

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PDE2A-IN-2

All Phosphodiesterase (PDE) Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

PDE2A-IN-2 Related Classifications

HY-180526 Related Classifications