2. Metabolic Enzyme/Protease
  3. Phosphodiesterase (PDE)
  4. TAK-915

TAK-915 is a potent, selective, brain-penetrant and orally active phosphodiesterase 2A (PDE2A) inhibitor with an IC50 of 0.61 nM. TAK-915 is >4100-fold more selectivity for PDE2A than PDE1A. TAK-915 has the potential for neuropsychiatric and neurodegenerative disorders treatment.

For research use only. We do not sell to patients.

TAK-915 Chemical Structure

TAK-915 Chemical Structure

CAS No. : 1476727-50-0

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Based on 1 publication(s) in Google Scholar

TAK-915 Related Antibodies

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PDE1 PDE2 PDE3 PDE4 PDE5 PDE6 PDE7 PDE9 PDE10 PDE11 PDE12 PDE8 Autotaxin

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Description

TAK-915 is a potent, selective, brain-penetrant and orally active phosphodiesterase 2A (PDE2A) inhibitor with an IC50 of 0.61 nM. TAK-915 is >4100-fold more selectivity for PDE2A than PDE1A. TAK-915 has the potential for neuropsychiatric and neurodegenerative disorders treatment[1][2].

IC50 & Target[1]

PDE2A

0.61 nM (IC50)

PDE1A

2497 nM (IC50)

In Vivo

TAK-915 (3 mg/kg; oral administration; daily; for 4 days; male F344 rats) treatment significantly reduces escape latency in aged rats in the Morris water maze task[2].
TAK-915 (1, 3, and 10 mg/kg, p.o.) dose-dependently attenuates the non-selective muscarinic antagonist scopolamine-induced memory deficits in rats[2].
Oral dosing of TAK-915 (compound 36) (3 or 10 mg/kg) in mice produces a dose-dependent increase in 3',5'-cyclic guanosine monophosphate (cGMP) levels, with significant cGMP increases observed at a dose of 10 mg/kg[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male F344 rats (10-week-old and 26-month-old) bearing morris water maze task[2]
Dosage: 3 mg/kg
Administration: Oral administration; daily; for 4 days
Result: Significantly reduced escape latency in aged rats in the Morris water maze task.
Clinical Trial
Molecular Weight

458.36

Formula

C19H18F4N4O5
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(N1)CN(C(N[C@@H](C2=CC(F)=C(OC(F)(F)F)C=C2)COC)=O)C3=C1C=C(OC)C=N3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 7.5 mg/mL (16.36 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1817 mL 10.9085 mL 21.8169 mL
5 mM 0.4363 mL 2.1817 mL 4.3634 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.74%

COA (249 KB) HNMR (316 KB) RP-HPLC (256 KB) LCMS (87 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1817 mL 10.9085 mL 21.8169 mL 54.5423 mL
5 mM 0.4363 mL 2.1817 mL 4.3634 mL 10.9085 mL
10 mM 0.2182 mL 1.0908 mL 2.1817 mL 5.4542 mL
15 mM 0.1454 mL 0.7272 mL 1.4545 mL 3.6362 mL
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TAK-915 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TAK-9151476727-50-0TAK915TAK 915Phosphodiesterase (PDE)PDE2ABBBcognitivedisordersstabilityoralneuropsychiatriccGMPInhibitorinhibitorinhibit

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