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Cat. No.: HY-120710

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DNS-8254

DNS-8254 is an oral active and brain-penetrating PDE2a inhibitor with the IC₅₀ of 8 nM. DNS-8254 shows memory enhancing effects in a rat model.

For research use only. We do not sell to patients.

CAS No.: 1821107-98-5
Formula: C₁₈H₁₅BrF₃N₅O
Molecular Weight:454.24

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

DNS-8254 Chemical Structure

CAS No.: 1821107-98-5

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

DNS-8254 is an oral active and brain-penetrating PDE2a inhibitor with the IC₅₀ of 8 nM. DNS-8254 shows memory enhancing effects in a rat model^[1].

All Phosphodiesterase (PDE) Isoforms :

Chemical Information

CAS No. 1821107-98-5
Molecular Weight 454.24
Formula C₁₈H₁₅BrF₃N₅O
SMILES

O=C(C1=CC=C(F)C(Br)=C1)N2CC(F)(F)C[C@H](C3=CC(C)=NC4=NC=NN34)C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Gomez L, et al. Design and Synthesis of Novel and Selective Phosphodiesterase 2 (PDE2a) Inhibitors for the Treatment of Memory Disorders. J Med Chem. 2017;60(5):2037-2051. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
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Chemical Information
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References

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DNS-8254

All Phosphodiesterase (PDE) Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

DNS-8254 Related Classifications

HY-120710 Related Classifications