PDE2A - phosphodiesterase 2A Gene

Also Known as PDE2A1; PED2A4; cGSPDE; CGS-PDE; IDDPADS

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5138

About PDE2A

Cytogenetic location: 11q13.4 Genomic coordinates (GRCh38): 11:72,576,141-72,674,422 (from NCBI)

This gene has 27 transcripts (splice variants), 215 orthologues, 20 paralogues and is associated with 2 phenotypes. Broad expression in spleen (RPKM 45.0), brain (RPKM 27.8) and 14 other tissues.

Summary

Enables several functions, including 3',5'-cyclic-nucleotide phosphodiesterase activity; anion binding activity; and metal ion binding activity. Involved in several processes, including cellular response to organic cyclic compound; cyclic-nucleotide-mediated signaling; and regulation of vascular permeability. Located in several cellular components, including cytosol; mitochondrial membrane; and perinuclear region of cytoplasm. Colocalizes with plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

PDE2A Products (5)

mRNA	Protein	Name
NM_001146209.3	NP_001139681.1	cGMP-dependent 3',5'-cyclic phosphodiesterase isoform PDE2A4
NM_002599.5	NP_002590.1	cGMP-dependent 3',5'-cyclic phosphodiesterase isoform PDE2A3
NM_001243784.2	NP_001230713.1	cGMP-dependent 3',5'-cyclic phosphodiesterase isoform PDE2A1
XM_005274040.4	XP_005274097.1	cGMP-dependent 3',5'-cyclic phosphodiesterase isoform X1
NM_001143839.4	NP_001137311.1	cGMP-dependent 3',5'-cyclic phosphodiesterase isoform PDE2A2 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables 3',5'-cGMP-stimulated cyclic-nucleotide phosphodiesterase activity	IDA IDA: Inferred from direct assay	17329248	GOA
enables 3',5'-cyclic-AMP phosphodiesterase activity	IDA IDA: Inferred from direct assay	9210593	GOA
enables 3',5'-cyclic-GMP phosphodiesterase activity	IDA IDA: Inferred from direct assay	9210593	GOA
enables TPR domain binding	IPI IPI: Inferred from physical interaction	17329248	GOA
enables cAMP binding	IMP IMP: Inferred from mutant phenotype	15938621	GOA
enables cGMP binding	IDA IDA: Inferred from direct assay	17329248	GOA
enables cGMP binding	IMP IMP: Inferred from mutant phenotype	15938621	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	19828435	GOA
enables magnesium ion binding	IDA IDA: Inferred from direct assay	15938621	GOA
enables phosphate ion binding	IDA IDA: Inferred from direct assay	15938621	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	17329248	GOA
enables protein homodimerization activity	IPI IPI: Inferred from physical interaction	19828435	GOA
enables zinc ion binding	IDA IDA: Inferred from direct assay	15938621	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	17329248	GOA
involved in cAMP-mediated signaling	IMP IMP: Inferred from mutant phenotype	17704206	GOA
involved in cGMP catabolic process	IDA IDA: Inferred from direct assay	19828435	GOA
involved in cGMP-mediated signaling	IMP IMP: Inferred from mutant phenotype	17704206	GOA
involved in cellular response to 2,3,7,8-tetrachlorodibenzodioxine	IDA IDA: Inferred from direct assay	17329248	GOA
involved in cellular response to cAMP	IDA IDA: Inferred from direct assay	17329248	GOA
involved in cellular response to cGMP	IDA IDA: Inferred from direct assay	17704206	GOA
involved in cellular response to granulocyte macrophage colony-stimulating factor stimulus	IDA IDA: Inferred from direct assay	14687666	GOA
involved in cellular response to macrophage colony-stimulating factor stimulus	IDA IDA: Inferred from direct assay	14687666	GOA
involved in cellular response to transforming growth factor beta stimulus	IEP IEP: Inferred from expression pattern	17704206	GOA
involved in cellular response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	14687666	GOA
involved in monocyte differentiation	IEP IEP: Inferred from expression pattern	14687666	GOA
involved in negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	19252089	GOA
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	17329248	GOA
involved in negative regulation of vascular permeability	IMP IMP: Inferred from mutant phenotype	17704206	GOA
involved in positive regulation of vascular permeability	IMP IMP: Inferred from mutant phenotype	17704206	GOA
involved in regulation of cAMP-mediated signaling	IMP IMP: Inferred from mutant phenotype	15938621	GOA
involved in regulation of cGMP-mediated signaling	IMP IMP: Inferred from mutant phenotype	15938621	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	10375378	GOA
located in cytosol	IDA IDA: Inferred from direct assay	17329248	GOA
located in mitochondrial inner membrane	IDA IDA: Inferred from direct assay	28463107	GOA
located in mitochondrial outer membrane	IDA IDA: Inferred from direct assay	28463107	GOA
located in nucleus	IDA IDA: Inferred from direct assay	10375378	GOA
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	10375378	GOA
colocalizes with plasma membrane	IDA IDA: Inferred from direct assay	17329248	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	19252089	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PDE2A Protein Structure

GAF

PDEase_I

0
200
400
600
800
941 a.a.

Protein Preferred Names	Protein Names
cGMP-dependent 3',5'-cyclic phosphodiesterase	cGMP-stimulated phosphodiesterase 1 cGMP-stimulated phosphodiesterase 2 cGMP-stimulated phosphodiesterase 4 cyclic GMP-stimulated phosphodiesterase phosphodiesterase 2A, cGMP-stimulated

PDE2A Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	PDE2A	O00408	AIP	Homo sapiens	O00170	Pull Down	17329248
Intra	PDE2A	O00408	AIP	Homo sapiens	O00170	Confocal	17329248
Intra	PDE2A	O00408	AIP	Homo sapiens	O00170	Anti Bait CoIP	17329248

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PDE2A Proteins

Cat. No.	Product Name	Accession	Purity
HY-P74647	PDE2A Protein, Human (sf9, His)	O00408 (E215-H900)	≥ 90%, as determined by reducing SDS-PAGE.

PDE2A Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83244	PDE2A Antibody (YA2989)	WB	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Scrotum Squamous Cell Carcinoma	Squamous Cell Carcinoma Of Scrotum Scrotal Squamous Cell Carcinoma
Transient Global Amnesia	Amnesia, Transient Global
Retinal Degeneration	Degeneration Of Retina
Paroxysmal Dystonia	Paroxysmal Dyskinesia Pxd - [Paroxysmal Dyskinesia]
Convulsions, Familial Infantile, With Paroxysmal Choreoathetosis	ICCA Icca Syndrome Infantile Convulsions And Choreoathetosis Infantile Convulsions And Paroxysmal Choreoathetosis, Familial Pkd/Ic Familial Infantile Convulsions And Paroxysmal Choreoathetosis Paroxysmal Kinesigenic Dyskinesia With Infantile Convulsions Convulsions, Infantile, With Paroxysmal Choreoathetosis, Familial Paroxysmal Kinesigenic Dyskinesia And Infantile Convulsions Icca Syndrome Paroxysmal Kinesigenic Dyskinesia With Infantile Convulsions Dyskinetic Syndrome
Paroxysmal Dyskinesia	Paroxysmal Choreoathetosis Paroxysmal Dystonic Choreoathetosis Paroxysmal Dyskinesias
Retinitis Pigmentosa	RP Rod-Cone Dystrophy Autosomal Recessive Retinitis Pigmentosa Non-Syndromic Retinitis Pigmentosa Pericentral Pigmentary Retinopathy Pigmentary Retinopathy Tapetoretinal Degeneration Rcd Retinitis Pigmentosa Autosomal Recessive ARRP Retinitis Pigmentosa, Autosomal Recessive Retinitis Pigmentosa 1
Choreatic Disease	Chorea Hereditary Chorea
Intellectual Developmental Disorder With Paroxysmal Dyskinesia Or Seizures	IDDPADS

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Phase
HY-112831	Osoresnontrine	Inhibitor	99.94%	Phase 2
HY-111167	AN-2898	Inhibitor	/	Phase 2
HY-111371	PF-05180999	Inhibitor	99.96%	Phase 1
HY-103493	TAK-915	Inhibitor	99.57%	Phase 1

Pre-clinical Phase

Bioactive Molecules (13)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-102050	PF-05085727	Inhibitor	99.53%	Unkown
HY-132993	Hcyb1	Inhibitor	98.20%	Unkown
HY-U00427	PDE2A-IN-3	Inhibitor	99.88%	Unkown
HY-102043	PDM-631	Inhibitor	/	Unkown
HY-112704	PDE5-IN-2	Inhibitor	/	Unkown
HY-120710	DNS-8254	Inhibitor	/	Unkown
HY-142660	PDE2A-IN-1	Inhibitor	/	Unkown
HY-168966	JNJ-54082730		/	Unkown
HY-180526	PDE2A-IN-2	Inhibitor	/	Unkown
HY-RS10213	PDE2A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS10214	Pde2a Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS10215	Pde2a Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-124173	PF-06815189	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	PDE2A	VGNC	VGNC:75912
Canis familiaris	PDE2A	VGNC	VGNC:44351
Felis catus	PDE2A	VGNC	VGNC:68755
Bos taurus	PDE2A	VGNC	VGNC:32674
Mus musculus	PDE2A	MGD	MGI:2446107
Rattus norvegicus	PDE2A	RGD	RGD:620965
Others	PDE2A	NCBI