2. Gene
  3. PDE2A - phosphodiesterase 2A Gene

PDE2A - phosphodiesterase 2A Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as PDE2A1; PED2A4; cGSPDE; CGS-PDE; IDDPADS

Gene ID: 5138 | Gene type: protein coding

About PDE2A

Cytogenetic location: 11q13.4 Genomic coordinates (GRCh38): 11:72,576,141-72,674,422 (from NCBI)

This gene has 27 transcripts (splice variants), 215 orthologues, 20 paralogues and is associated with 2 phenotypes. Broad expression in spleen (RPKM 45.0), brain (RPKM 27.8) and 14 other tissues.

Summary

Enables several functions, including 3',5'-cyclic-nucleotide phosphodiesterase activity; anion binding activity; and metal ion binding activity. Involved in several processes, including cellular response to organic cyclic compound; cyclic-nucleotide-mediated signaling; and regulation of vascular permeability. Located in several cellular components, including cytosol; mitochondrial membrane; and perinuclear region of cytoplasm. Colocalizes with plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

PDE2A Products(5)

mRNA Protein Name
NM_001146209.3 NP_001139681.1 cGMP-dependent 3',5'-cyclic phosphodiesterase isoform PDE2A4
NM_002599.5 NP_002590.1 cGMP-dependent 3',5'-cyclic phosphodiesterase isoform PDE2A3
NM_001243784.2 NP_001230713.1 cGMP-dependent 3',5'-cyclic phosphodiesterase isoform PDE2A1
XM_005274040.4 XP_005274097.1 cGMP-dependent 3',5'-cyclic phosphodiesterase isoform X1
NM_001143839.4 NP_001137311.1 cGMP-dependent 3',5'-cyclic phosphodiesterase isoform PDE2A2 precursor

PDE2A Protein Structure

GAF

GAF: GAF domain (248 - 367)

GAF

GAF: GAF domain (409 - 548)

PDEase_I

PDEase_I: 3'5'-cyclic nucleotide phosphodiesterase (655 - 892)

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  • 941 a.a.
Protein Preferred Names Protein Names

cGMP-dependent 3',5'-cyclic phosphodiesterase

cGMP-stimulated phosphodiesterase 1

cGMP-stimulated phosphodiesterase 2

cGMP-stimulated phosphodiesterase 4

cyclic GMP-stimulated phosphodiesterase

phosphodiesterase 2A, cGMP-stimulated

Recombinant PDE2A Proteins

Cat. No. Product Name Accession Purity
HY-P74647 PDE2A Protein, Human (sf9, His) O00408 (E215-H900) ≥95%

Related Diseases

Diseases Alias
Scrotum Squamous Cell Carcinoma

Squamous Cell Carcinoma Of Scrotum

Scrotal Squamous Cell Carcinoma
Transient Global Amnesia

Amnesia, Transient Global
Retinal Degeneration

Degeneration Of Retina
Paroxysmal Dystonia

Paroxysmal Dyskinesia

Pxd - [Paroxysmal Dyskinesia]
Convulsions, Familial Infantile, With Paroxysmal Choreoathetosis

ICCA

Icca Syndrome

Infantile Convulsions And Choreoathetosis

Infantile Convulsions And Paroxysmal Choreoathetosis, Familial

Pkd/Ic

Familial Infantile Convulsions And Paroxysmal Choreoathetosis

Paroxysmal Kinesigenic Dyskinesia With Infantile Convulsions

Convulsions, Infantile, With Paroxysmal Choreoathetosis, Familial

Paroxysmal Kinesigenic Dyskinesia And Infantile Convulsions

Icca Syndrome Paroxysmal Kinesigenic Dyskinesia With Infantile Convulsions

Dyskinetic Syndrome
Paroxysmal Dyskinesia

Paroxysmal Choreoathetosis

Paroxysmal Dystonic Choreoathetosis

Paroxysmal Dyskinesias
Retinitis Pigmentosa

RP

Rod-Cone Dystrophy

Autosomal Recessive Retinitis Pigmentosa

Non-Syndromic Retinitis Pigmentosa

Pericentral Pigmentary Retinopathy

Pigmentary Retinopathy

Tapetoretinal Degeneration

Rcd

Retinitis Pigmentosa Autosomal Recessive

ARRP

Retinitis Pigmentosa, Autosomal Recessive

Retinitis Pigmentosa 1
Choreatic Disease

Chorea

Hereditary Chorea
Intellectual Developmental Disorder With Paroxysmal Dyskinesia Or Seizures

IDDPADS
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Phase
HY-112831 Osoresnontrine Inhibitor 99.88% Phase 2
HY-111371 PF-05180999 Inhibitor 99.97% Phase 1
HY-103493 TAK-915 Inhibitor 99.74% Phase 1
Pre-clinical Phase
Bioactive Molecules (7)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-102050 PF-05085727 Inhibitor 99.60% Unkown
HY-132993 Hcyb1 Inhibitor 98.24% Unkown
HY-112704 PDE5-IN-2 Inhibitor / Unkown
HY-142660 PDE2A-IN-1 Inhibitor / Unkown
HY-RS10213 PDE2A Human Pre-designed siRNA Set A / Unkown
HY-RS10214 Pde2a Mouse Pre-designed siRNA Set A / Unkown
HY-RS10215 Pde2a Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta PDE2A VGNC VGNC:75912
Canis familiaris PDE2A VGNC VGNC:44351
Felis catus PDE2A VGNC VGNC:68755
Bos taurus PDE2A VGNC VGNC:32674
Mus musculus PDE2A MGD MGI:2446107
Rattus norvegicus PDE2A RGD RGD:620965
Others PDE2A NCBI