PDE2A Antibody (YA2989)
(Synonyms: CGS PDE; cGSPDE; PDE2A; PDE2A1; PDE2A4; phosphodiesterase 2A)
Based on 1 Customer Validation
PDE2A Antibody (YA2989) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PDE2A.
-
Host:
Rabbit
-
Isotype:
IgG
-
Application:
WB
-
Reactivity :
Human, Mouse, Rat
-
Formulation:
Supplied in Rabbit IgG in 10mM phosphate buffered saline , pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.
-
Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
|
|---|---|
| Dilution Ratio | 1:500-1:1000 |
Product Details
PDE2A Antibody (YA2989) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PDE2A.
-
Host Rabbit
-
Clonality Recombinant, Monoclonal
-
Species ReactivityHuman, Mouse, Rat
-
Observed Molecular WeightObserved band size: 106 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
-
Calculated Molecular Weight Predicted band size: 106 kDa
Entrez Gene: 5138 Human ; 207728 Mouse ; 81743 Rat
SwissProt: O00408 Human ; Q922S4 Mouse ; Q01062 Rat
OMIM: 619150 Human
A synthesized peptide derived from human PDE2A aa1-76.
Endogenous
Affinity Purified
Non-conjugated
Unmodified
IgG
Product Properties
-
Appearance
Liquid
-
Formulation
Supplied in Rabbit IgG in 10mM phosphate buffered saline , pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.
-
Concentration
Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration
-
Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
-
Shipping
Shipping with blue ice.
Background
-
Function
PDE2A is a cGMP-activated cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a higher efficiency with cGMP compared to cAMP. Plays a role in cell growth and migration; Regulates mitochondrial cAMP levels and respiration. Involved in the regulation of mitochondria morphology/dynamics and apoptotic cell death via local modulation of cAMP/PKA signaling in the mitochondrion, including the monitoring of local cAMP levels at the outer mitochondrial membrane and of PKA-dependent phosphorylation of DNM1L[1][2][3][4][5].
-
Subcellular Localization
Cell membrane; Lipid-anchor; Mitochondrion matrix; Mitochondrion inner membrane; Mitochondrion outer membrane; Cytoplasm; Mitochondrion
-
Expression
Tissue_specificity:Widely expressed (PubMed:29392776, PubMed:9210593) . Expressed in brain, with high expression observed in the corpus striatum (PubMed:29392776) . Also expressed in heart, placenta, lung, skeletal muscle, kidney and pancreas (PubMed:29392776, PubMed:9210593) -
Isoforms & Post-Translational Modification
O00408 has 6 isomers: O00408-1: 105717 Da (predicted); O00408-2: 103478 Da (predicted); O00408-3: 105147 Da (predicted); O00408-4: 104955 Da (predicted); O00408-5: 78177 Da (predicted); O00408-6: 87235 Da (predicted).
-
Subunit
Homodimer
-
SwissProt ID
-
Synonyms
CGS PDE; cGSPDE; PDE2A; PDE2A1; PDE2A4; phosphodiesterase 2A
-
Research Field
-
Documentation
-
Data Sheet (231 KB)
-
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
-
User Guide for Antibodies (1077 KB)
Powered by Bioz
