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TMEM79 - transmembrane protein 79 Gene

Also Known as MATT

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 84283

About TMEM79

Cytogenetic location: 1q22 Genomic coordinates (GRCh38): 1:156,282,932-156,292,443 (from NCBI)

This gene has 7 transcripts (splice variants) and 259 orthologues. Biased expression in skin (RPKM 34.9), esophagus (RPKM 32.0) and 6 other tissues.

Summary

Enables identical protein binding activity. Predicted to be involved in several processes, including epithelial cell maturation; establishment of skin barrier; and positive regulation of epidermis development. Predicted to act upstream of or within cornification; cuticle development; and hair follicle morphogenesis. Predicted to be located in cytoplasm. Predicted to be active in lysosomal membrane and trans-Golgi network membrane. [provided by Alliance of Genome Resources, Apr 2022]

TMEM79 Products (1)

mRNA	Protein	Name
NM_032323.3	NP_115699.1	transmembrane protein 79

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Verweise	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	21516116	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
transmembrane protein 79	mattrin

TMEM79 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	TMEM79	Q9BSE2	LDLRAD1	Homo sapiens	Q5T700	Y2H Prey Pooling	32296183
Intra	TMEM79	Q9BSE2	LDLRAD1	Homo sapiens	Q5T700	Y2H Array	32296183
Intra	TMEM79	Q9BSE2	ABO	Homo sapiens	B0B1U2	Y2H Prey Pooling	25416956
Intra	TMEM79	Q9BSE2	ABO	Homo sapiens	B0B1U2	Validated Y2H	25416956
Intra	TMEM79	Q9BSE2	ABO	Homo sapiens	B0B1U2	Y2H Array	25416956
Intra	TMEM79	Q9BSE2	SFTPC	Homo sapiens	P11686	Y2H Prey Pooling	25416956
Intra	TMEM79	Q9BSE2	SFTPC	Homo sapiens	P11686	Y2H Array	31515488
Intra	TMEM79	Q9BSE2	SFTPC	Homo sapiens	P11686	Validated Y2H	25416956
Intra	TMEM79	Q9BSE2	TNMD	Homo sapiens	Q9H2S6	Y2H Prey Pooling	25416956
Intra	TMEM79	Q9BSE2	TNMD	Homo sapiens	Q9H2S6	Validated Y2H	25416956
Intra	TMEM79	Q9BSE2	TMPRSS4	Homo sapiens	Q9NRS4-3	Y2H Array	25416956
Intra	TMEM79	Q9BSE2	TMPRSS4	Homo sapiens	Q9NRS4-3	Y2H Prey Pooling	25416956
Intra	TMEM79	Q9BSE2	TMPRSS4	Homo sapiens	Q9NRS4	Validated Y2H	25416956
Intra	TMEM79	Q9BSE2	TMPRSS4	Homo sapiens	Q9NRS4	Y2H Array	25416956
Intra	TMEM79	Q9BSE2	TMPRSS4	Homo sapiens	Q9NRS4	Y2H Prey Pooling	25416956
Intra	TMEM79	Q9BSE2	TEX264	Homo sapiens	Q9Y6I9	Complementation	32296183
Intra	TMEM79	Q9BSE2	TEX264	Homo sapiens	Q9Y6I9	Y2H Prey Pooling	25416956
Intra	TMEM79	Q9BSE2	TEX264	Homo sapiens	Q9Y6I9	Validated Y2H	32296183
Intra	TMEM79	Q9BSE2	TEX264	Homo sapiens	Q9Y6I9	Y2H Array	25416956
Intra	TMEM79	Q9BSE2	SERP1	Homo sapiens	Q9Y6X1	Y2H Array	25416956
Intra	TMEM79	Q9BSE2	SERP1	Homo sapiens	Q9Y6X1	Validated Y2H	25416956
Intra	TMEM79	Q9BSE2	CYB5R3	Homo sapiens	P00387	Y2H Prey Pooling	32296183
Intra	TMEM79	Q9BSE2	CYB5R3	Homo sapiens	P00387	Y2H Array	32296183
Intra	TMEM79	Q9BSE2	RPRM	Homo sapiens	Q9NS64	Y2H Prey Pooling	25416956
Intra	TMEM79	Q9BSE2	RPRM	Homo sapiens	Q9NS64	Validated Y2H	25416956
Intra	TMEM79	Q9BSE2	RPRM	Homo sapiens	Q9NS64	Validated Y2H	32296183
Intra	TMEM79	Q9BSE2	RPRM	Homo sapiens	Q9NS64	Y2H Array	25416956
Intra	TMEM79	Q9BSE2	ARL13B	Homo sapiens	Q3SXY8	Y2H Array	32296183
Intra	TMEM79	Q9BSE2	ARL13B	Homo sapiens	Q3SXY8	Y2H Prey Pooling	32296183
Intra	TMEM79	Q9BSE2	CLEC7A	Homo sapiens	Q9BXN2-6	Validated Y2H	32296183
Intra	TMEM79	Q9BSE2	TNMD	Homo sapiens	Q9H2S6-2	Validated Y2H	32296183
Intra	TMEM79	Q9BSE2	LPAR3	Homo sapiens	Q9UBY5	Validated Y2H	32296183
Intra	TMEM79	Q9BSE2	FNDC9	Homo sapiens	Q8TBE3	Y2H Array	32296183
Intra	TMEM79	Q9BSE2	FNDC9	Homo sapiens	Q8TBE3	Y2H Prey Pooling	32296183
Intra	TMEM79	Q9BSE2	GPRC5D	Homo sapiens	Q9NZD1	Y2H Array	32296183
Intra	TMEM79	Q9BSE2	GPRC5D	Homo sapiens	Q9NZD1	Y2H Prey Pooling	32296183
Intra	TMEM79	Q9BSE2	GPRC5D	Homo sapiens	Q9NZD1	Validated Y2H	32296183
Intra	TMEM79	Q9BSE2	CPLX4	Homo sapiens	Q7Z7G2	Y2H Prey Pooling	32296183
Intra	TMEM79	Q9BSE2	CPLX4	Homo sapiens	Q7Z7G2	Y2H Array	32296183
Intra	TMEM79	Q9BSE2	FAM209A	Homo sapiens	Q5JX71	Y2H Prey Pooling	32296183
Intra	TMEM79	Q9BSE2	FAM209A	Homo sapiens	Q5JX71	Y2H Array	32296183
Intra	TMEM79	Q9BSE2	AMIGO1	Homo sapiens	Q86WK6	Y2H Array	32296183
Intra	TMEM79	Q9BSE2	AMIGO1	Homo sapiens	Q86WK6	Y2H Prey Pooling	32296183
Intra	TMEM79	Q9BSE2	GCNT2	Homo sapiens	Q8N0V5	Anti Tag CoIP	33961781
Intra	TMEM79	Q9BSE2	GCNT2	Homo sapiens	Q8N0V5	Anti Tag CoIP	28514442
Intra	TMEM79	Q9BSE2	TMEM14C	Homo sapiens	Q9P0S9	Validated Y2H	32296183
Intra	TMEM79	Q9BSE2	RNF8	Homo sapiens	O76064	Y2H Array	32296183
Intra	TMEM79	Q9BSE2	RNF8	Homo sapiens	O76064	Validated Y2H	25416956
Intra	TMEM79	Q9BSE2	RNF8	Homo sapiens	O76064	Y2H Prey Pooling	32296183
Intra	TMEM79	Q9BSE2	CLEC7A	Homo sapiens	Q9BXN2	Validated Y2H	25416956
Intra	TMEM79	Q9BSE2	PELI2	Homo sapiens	Q9HAT8	Validated Y2H	32296183
Intra	TMEM79	Q9BSE2	PLP2	Homo sapiens	Q04941	Y2H Prey Pooling	25416956
Intra	TMEM79	Q9BSE2	PLP2	Homo sapiens	Q04941	Validated Y2H	25416956
Intra	TMEM79	Q9BSE2	PLP2	Homo sapiens	Q04941	Y2H Array	25416956
Intra	TMEM79	Q9BSE2	COQ9	Homo sapiens	O75208	Y2H Prey Pooling	32296183
Intra	TMEM79	Q9BSE2	COQ9	Homo sapiens	O75208	Y2H Array	32296183
Intra	TMEM79	Q9BSE2	ZCCHC12	Homo sapiens	Q6PEW1	Y2H Prey Pooling	32296183
Intra	TMEM79	Q9BSE2	ZCCHC12	Homo sapiens	Q6PEW1	Y2H Array	32296183
Intra	TMEM79	Q9BSE2	TMEM100	Homo sapiens	Q9NV29	Y2H Prey Pooling	25416956
Intra	TMEM79	Q9BSE2	TMEM100	Homo sapiens	Q9NV29	Validated Y2H	25416956
Intra	TMEM79	Q9BSE2	TMEM100	Homo sapiens	Q9NV29	Y2H Array	25416956
Intra	TMEM79	Q9BSE2	SEC22A	Homo sapiens	Q96IW7	Y2H Array	25416956
Intra	TMEM79	Q9BSE2	SEC22A	Homo sapiens	Q96IW7	Y2H Prey Pooling	25416956
Intra	TMEM79	Q9BSE2	SEC22A	Homo sapiens	Q96IW7	Validated Y2H	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Dermatitis	Eczema Skin Inflammation Inflammatory Dermatosis
Dermatitis, Atopic	Atopic Dermatitis Atopic Eczema Dermatitis, Atopic, Susceptibility To, 1 Atod Eczema, Atopic Dermatitis, Atopic 1 Allergic Dermatitis Atopic Neurodermatitis Besnier'S Prurigo Dermatitis, Atopic, 1 Dermatitis Atopic Eczema Besnier Prurigo
Psoriasis 13	PSORS13 Psoriasis 13, Susceptibility To Psoriasis Psoriasis Vulgaris Psoriasis Susceptibility 13 Pv Psoriasis, Susceptibility To, Type 13
Ichthyosis Vulgaris	Ichthyosis Simplex Dominant Congenital Ichthyosiform Erythroderma Common Ichthyosis Fish Scale Disease VI Ichthyoses Congenital Ichthyosis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-RS14742	TMEM79 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	TMEM79	VGNC	VGNC:66363
Mus musculus	TMEM79	MGD	MGI:1919163
Macaca mulatta	TMEM79	VGNC	VGNC:106521
Bos taurus	TMEM79	VGNC	VGNC:36112
Rattus norvegicus	TMEM79	RGD	RGD:1309886
Canis familiaris	TMEM79	VGNC	VGNC:47605
Others	TMEM79	NCBI