Mofebutazone sodium
Mofebutazone sodium is a pyrazolidinedione non-steroidal anti-inflammatory agent (NSAID). Mofebutazone sodium exhibits weak COX inhibition, no effect on LOX, and slightly suppresses the percentage of leukocyte phagocytosis in vitro. Mofebutazone sodium can be used in research related to soft tissue rheumatism.
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- CAS. Nr.: 41468-34-2
- Formel: C13H15N2NaO2
- Molecular Weight:254.26
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
Mofebutazone (10 nM-1 mM; 30 min) sodium reduces the proportion of phagocytic polymorphonuclear leukocytes and monocytes in peripheral blood from healthy donors and patients with soft tissue rheumatism, but does not alter the number of bacteria phagocytosed by individual cells[1].
Mofebutazone (10 nM-1 mM; 30 min) sodium inhibits the release of respiratory burst oxidative products in peripheral blood leukocytes from healthy donors and patients with soft tissue rheumatism in a concentration-dependent manner[1].
Mofebutazone sodium does not inhibit cyclooxygenase activity in isolated rat and human gastric mucosa[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 41468-34-2
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Molecular Weight 254.26
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Formel C13H15N2NaO2
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SMILES
O=C(C1CCCC)[N-]N(C2=CC=CC=C2)C1=O.[Na+]
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Neumüller J, et al. Comparative in vitro investigations of the influence of mofebutazone, phenylbutazone and diclofenac on phagocytosis and respiratory burst of human peripheral blood leucocytes. Arzneimittel-Forschung. 1994 May;44(5):636-41. [Content Brief]
[2]. Coersmeier C, et al. Effect of anti-inflammatory and analgesic pyrazoles on arachidonic acid metabolism in isolated heart and gastric mucosa preparations. Agents and actions. Supplements. 1986;19:137-54. [Content Brief]
[3]. Lanz R, et al. The effects of acidic and nonacidic pyrazoles on arachidonic acid metabolism in mouse peritoneal macrophages. Agents and actions. Supplements. 1986;19:125-35. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Mofebutazone sodium Related Classifications
HY-W009640A Related Classifications
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