(S)-(+)-Ibuprofen-d3
Based on 1 Customer Validation
(S)-(+)-Ibuprofen-d3 is a deuterium labeled (S)-(+)-Ibuprofen. (S)-(+)-Ibuprofen is the S(+)-enantiomer of Ibuprofen that inhibits COX-1 and COX-2 activity with IC50s of 2.1 μM and 1.6 μM. (S)-(+)-Ibuprofen has analgesic, antiinflammatory and antipyretic effects.
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- Reinheit: 99.96%
- CAS. Nr.: 1329643-44-8
- Formel: C13H15D3O2
- Molecular Weight:209.30
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Speicherung:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
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COX-1 2.1 μM (IC50) |
COX-2 1.6 μM (IC50) |
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS. Nr. 1329643-44-8
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Unlabeled Cas 51146-56-6
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Appearance Solid
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Molecular Weight 209.30
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Formel C13H15D3O2
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Color White to off-white
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SMILES
OC([C@H](C1=CC=C(CC(C)C)C=C1)C([2H])([2H])[2H])=O
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Synonyms
(S)-Ibuprofen d3
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Lösungsmittel & Löslichkeit
DMSO : 100 mg/mL (477.78 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Ethanol : 100 mg/mL (477.78 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (273 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. Evans AM, et al. Comparative pharmacology of S(+)-ibuprofen and (RS)-ibuprofen. Clin Rheumatol. 2001 Nov;20 Suppl 1:S9-14. [Content Brief]
[2]. Xu HR, et al. The effect of CYP2C19 activity on pharmacokinetics of lansoprazole and its active metabolites in healthy subjects. Pharm Biol. 2010 Aug;48(8):947-52. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / Ethanol | 1 mM | 4.7778 mL | 23.8892 mL | 47.7783 mL | 119.4458 mL |
| 5 mM | 0.9556 mL | 4.7778 mL | 9.5557 mL | 23.8892 mL | |
| 10 mM | 0.4778 mL | 2.3889 mL | 4.7778 mL | 11.9446 mL | |
| 15 mM | 0.3185 mL | 1.5926 mL | 3.1852 mL | 7.9631 mL | |
| 20 mM | 0.2389 mL | 1.1945 mL | 2.3889 mL | 5.9723 mL | |
| 25 mM | 0.1911 mL | 0.9556 mL | 1.9111 mL | 4.7778 mL | |
| 30 mM | 0.1593 mL | 0.7963 mL | 1.5926 mL | 3.9815 mL | |
| 40 mM | 0.1194 mL | 0.5972 mL | 1.1945 mL | 2.9861 mL | |
| 50 mM | 0.0956 mL | 0.4778 mL | 0.9556 mL | 2.3889 mL | |
| 60 mM | 0.0796 mL | 0.3982 mL | 0.7963 mL | 1.9908 mL | |
| 80 mM | 0.0597 mL | 0.2986 mL | 0.5972 mL | 1.4931 mL | |
| 100 mM | 0.0478 mL | 0.2389 mL | 0.4778 mL | 1.1945 mL |
(S)-(+)-Ibuprofen-d3 Related Classifications
HY-78131AS Related Classifications
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