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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
268 Results for "
Insulin secretion
" in MedChemExpress (MCE) Product Catalog:
Products (268)
268 Results for "Insulin secretion" in MCE Product Catalog:
45
45 Publications Verification
Forschungsgebiete:
45
45 Publications Verification
Forschungsgebiete:
45
45 Publications Verification
Art. -Nr.: HY-114118A
Reinheit: 99.92%
Forschungsgebiete:
42
42 Cited Publications
Art. -Nr.: HY-P0014B
Target:
Forschungsgebiete:
12
12 Cited Publications
Art. -Nr.: HY-W016715
CAS. Nr.: 7048-04-6
11
11 Cited Publications
Synonyms: RC-1291; ONO-7643
Target:
Forschungsgebiete:
Anamorelin (RC-1291) is an orally active Ghrelin receptor agonist with an EC50 of 0.74 nM. Anamorelin can promote appetite, increase body weight, and stimulate the secretion of growth hormone and insulin-like growth factor-1. Anamorelin can be used in the research of anorexia and cancer cachexia .
11
11 Cited Publications
Synonyms: RC-1291 hydrochloride; ONO-7643 hydrochloride
Target:
Forschungsgebiete:
Anamorelin (RC-1291) hydrochloride is an orally active Ghrelin receptor agonist with an EC50 of 0.74 nM. Anamorelin hydrochloride can promote appetite, increase body weight, and stimulate the secretion of growth hormone and insulin-like growth factor-1. Anamorelin hydrochloride can be used in the research of anorexia and cancer cachexia .
10
10 Cited Publications
Art. -Nr.: HY-P0055
CAS. Nr.: 106612-94-6
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Forschungsgebiete:
10
10 Cited Publications
Art. -Nr.: HY-P0054A
CAS. Nr.: 107444-51-9
Synonyms: Glucagon-like peptide-1 (GLP-1)(7-36), amide; Human GLP-1 (7-36), amide
Target:
Forschungsgebiete:
10
10 Cited Publications
Art. -Nr.: HY-P0054
CAS. Nr.: 1119517-19-9
Synonyms: Glucagon-like peptide-1 (GLP-1)(7-36), amide acetate; Human GLP-1 (7-36), amide acetate
Target:
Forschungsgebiete:
10
10 Cited Publications
Art. -Nr.: HY-P0055A
CAS. Nr.: 1450806-98-0
Target:
Forschungsgebiete:
10
10 Cited Publications
Art. -Nr.: HY-P0054B
Synonyms: Glucagon-like peptide-1 (GLP-1)(7-36), amide TFA; Human GLP-1 (7-36), amide TFA
Target:
Forschungsgebiete:
8
Target:
Forschungsgebiete:
Phentolamine is an orally active, selective α1 and α2 Adrenergic receptor antagonist. Phentolamine antagonizes the vasodilatory effect of Cromakalim (HY-110011) on isolated circumflex coronary artery segments in dogs. Phentolamine reduces systemic vascular resistance and increases cardiac output. Phentolamine improves erectile dysfunction. Phentolamine can be used for the research of erectile dysfunction .
7
7 Cited Publications
Art. -Nr.: HY-16307
CAS. Nr.: 261365-11-1
Target:
Forschungsgebiete:
MB05032 is a fructose-1,6-bisphosphatase (FBP1/FBPase) inhibitor with an IC50 value of 16 nM. MB05032 blocks FBP1-mediated glycolysis inhibition in NK cells, restores NK cell glucose uptake, lactate production, degranulation, perforin production, and cytotoxicity against gastric cancer cells. MB05032 elevates ATP/ADP ratios, increases glucose utilization, and enhances insulin secretion in pancreatic β-cells. MB05032 increases neutrophil adhesion, phagocytosis, and mRNA abundance of HKII, ITGA9, CD36 in subclinically hypocalcemic dairy cows. MB05032 inhibits gluconeogenesis in hepatocytes, acts as the active metabolite of prodrug Managlinat dialanetil (MB06322) (HY-14955). MB05032 can be used for the research of gastric cancer, type 2 diabetes, subclinical hypocalcemia, and insulin resistance .
6
6 Cited Publications
Synonyms: Arachidonyl trifluoromethyl ketone
Target:
Forschungsgebiete:
AACOCF3 (Arachidonyl trifluoromethyl ketone) is a cell-permeant trifluoromethyl ketone analog of arachidonic acid. AACOCF3 is a potent and selective slow binding inhibitor of the 85-kDa cytosolic phospholipase A2 (cPLA2). AACOCF3 blocks production of arachidonate and 12-hydroxyeicosatetraenoic acid by calcium ionophore-challenged platelets. AACOCF3 inhibits glucose-induced insulin secretion from isolated rat islets. AACOCF3 has the potential for the research of cardiovascular disease .
6
Target:
Forschungsgebiete:
MDL12330A (RMI12330A) is an adenylyl cyclases inhibitor. MDL12330A can inhibit KV channels, increases insulin secretion and Ca 2+ levels. MDL12330A accentuates contractions in uterine rings and inhibits cardiac functions. MDL12330A can be used for the research of endocrinology, metabolic and cardiovascular disease .
5
5 Cited Publications
4
4 Cited Publications
Synonyms: Neu5Ac2en; DANA
Target:
Forschungsgebiete:
N-acetyl-2,3-dehydro-2-Deoxyneuraminic Acid (Neu5Ac2en) is a potent neuraminidase (sialidase) inhibitor. N-acetyl-2,3-dehydro-2-Deoxyneuraminic Acid shows inhibitory activities against human neuraminidase enzymes with IC50s of 143, 43, 61, and 74 μM for NEU1, NEU2, NEU3, and NEU4, respectively. Anti-influenza virus activity .
4
Target:
Forschungsgebiete:
ESI-05 is a specific exchange proteins directly activated by cAMP 2 (EPAC2) inhibitor. ESI-05 inhibits cAMP-mediated EPAC2 GEF activity with an IC50 of 0.43 μM. ESI-05 can be used for the research of diabetes, insulin secretion and neurological disorders .
3
3 Cited Publications
Art. -Nr.: HY-W030796A
CAS. Nr.: 150436-68-3
Target:
Forschungsgebiete:
Lactisole is a canonical antagonist of sweet taste receptor, selectively targeting to T1R3 subunit, a glucose-sensing receptor. Lactisole inhibits insulin secretion induced by glucose in mouse islets .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
