150436-68-3
150436-68-3
Chemical Structure
Lactisole
- CAS No.: 150436-68-3
- Formula:C10H11NaO4
- Molecular Weight:218.18
IUPAC Name: sodium 2-(4-methoxyphenoxy)propanoate
InChIKey: SKORRGYRKQDXRS-UHFFFAOYSA-M
SMILES: COC1=CC=C(C=C1)OC(C(O[Na])=O)C
Biological Activity: Lactisole is a canonical antagonist of sweet taste receptor, selectively targeting to T1R3 subunit, a glucose-sensing receptor. Lactisole inhibits insulin secretion induced by glucose in mouse islets[1][2].
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Lactisole | 99.79% | Lactisole is a canonical antagonist of sweet taste receptor, selectively targeting to T1R3 subunit, a glucose-sensing receptor. Lactisole inhibits insulin secretion induced by glucose in mouse islets. | ||||||||||||||||||||
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Lactisole (Standard) | ≥98% | Bisdemethoxycucurmin (Standard) is the analytical standard of Bisdemethoxycucurmin. This product is intended for research and analytical applications. Bisdemethoxycucurmin (Curcumin III), a curcuminoid, has antioxidant and antiinflammatory activities. | ||||||||||||||||||||
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References
- [1]. Hamano K, et al. Lactisole inhibits the glucose-sensing receptor T1R3 expressed in mouse pancreatic β-cells. J Endocrinol. 2015 Jul;226(1):57-66. [Content Brief]
- [2]. Schweiger K, et al. Sweet Taste Antagonist Lactisole Administered in Combination with Sucrose, But Not Glucose, Increases Energy Intake and Decreases Peripheral Serotonin in Male Subjects. Nutrients. 2020 Oct 14;12(10):3133. [Content Brief]
