5184-64-5
5184-64-5
Chemical Structure
ESI-05
Synonym(s): NSC 116966
- CAS No.: 5184-64-5
- Formula:C16H18O2S
- Molecular Weight:274.38
IUPAC Name: 1,3,5-trimethyl-2-tosylbenzene
InChIKey: CGPHOZWFSFNOEQ-UHFFFAOYSA-N
SMILES: O=S(C1=C(C)C=C(C)C=C1C)(C2=CC=C(C)C=C2)=O
Biological Activity: ESI-05 is a specific exchange proteins directly activated by cAMP 2 (EPAC2) inhibitor. ESI-05 inhibits cAMP-mediated EPAC2 GEF activity with an IC50 of 0.43 μM. ESI-05 can be used for the research of diabetes, insulin secretion and neurological disorders[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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ESI-05 | 99.78% | ESI-05 is a specific exchange proteins directly activated by cAMP 2 (EPAC2) inhibitor. ESI-05 inhibits cAMP-mediated EPAC2 GEF activity with an IC50 of 0.43 μM. ESI-05 can be used for the research of diabetes, insulin secretion and neurological disorders. | ||||||||||||||||||||
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References
- [1]. Tsalkova T, et al. Isoform-specific antagonists of exchange proteins directly activated by cAMP. Proc Natl Acad Sci U S A. 2012 Nov 6;109(45):18613-8. [Content Brief]
- [2]. Yan Zhuang, et al. Inhibition of EPAC2 Attenuates Intracerebral Hemorrhage-Induced Secondary Brain Injury via the p38/BIM/Caspase-3 Pathway. J Mol Neurosci. 2019 Mar;67(3):353-363. [Content Brief]
