261365-11-1
Chemical Structure
MB05032
- CAS. Nr.: 261365-11-1
- Formula:C11H15N2O4PS
- Molecular Weight:302.29
IUPAC Name: (5-(2-amino-5-isobutylthiazol-4-yl)furan-2-yl)phosphonic acid
InChIKey: XJMYIJPPDSZOPN-UHFFFAOYSA-N
SMILES: CC(C)CC1=C(C2=CC=C(P(O)(O)=O)O2)N=C(N)S1
Biological Activity: MB05032 is a fructose-1,6-bisphosphatase (FBP1/FBPase) inhibitor with an IC50 value of 16 nM. MB05032 blocks FBP1-mediated glycolysis inhibition in NK cells, restores NK cell glucose uptake, lactate production, degranulation, perforin production, and cytotoxicity against gastric cancer cells. MB05032 elevates ATP/ADP ratios, increases glucose utilization, and enhances insulin secretion in pancreatic β-cells. MB05032 increases neutrophil adhesion, phagocytosis, and mRNA abundance of HKII, ITGA9, CD36 in subclinically hypocalcemic dairy cows. MB05032 inhibits gluconeogenesis in hepatocytes, acts as the active metabolite of prodrug Managlinat dialanetil (MB06322) (HY-14955). MB05032 can be used for the research of gastric cancer, type 2 diabetes, subclinical hypocalcemia, and insulin resistance[1][2][3][4][5].
| Art. -Nr. | Produktname | Reinheit | Beschreibung | Pricing | |||||||||||||||||||
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MB05032 | 99.63% | MB05032 is a fructose-1,6-bisphosphatase (FBP1/FBPase) inhibitor with an IC50 value of 16 nM. MB05032 blocks FBP1-mediated glycolysis inhibition in NK cells, restores NK cell glucose uptake, lactate production, degranulation, perforin production, and cytotoxicity against gastric cancer cells. MB05032 elevates ATP/ADP ratios, increases glucose utilization, and enhances insulin secretion in pancreatic β-cells. MB05032 increases neutrophil adhesion, phagocytosis, and mRNA abundance of HKII, ITGA9, CD36 in subclinically hypocalcemic dairy cows. MB05032 inhibits gluconeogenesis in hepatocytes, acts as the active metabolite of prodrug Managlinat dialanetil (MB06322) (HY-14955). MB05032 can be used for the research of gastric cancer, type 2 diabetes, subclinical hypocalcemia, and insulin resistance. | ||||||||||||||||||||
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- [1]. Han F, et al. Gastric cancer mesenchymal stem cells inhibit natural killer cell function by up-regulating FBP1. Central-European journal of immunology. 2021;46(4):427-437. [Content Brief]
- [2]. Zhang Y, et al. Fructose-1,6-bisphosphatase regulates glucose-stimulated insulin secretion of mouse pancreatic beta-cells. Endocrinology. 2010 Oct;151(10):4688-95. [Content Brief]
- [3]. Zhang B, et al. Store-operated Ca entry-sensitive glycolysis regulates neutrophil adhesion and phagocytosis in dairy cows with subclinical hypocalcemia. Journal of dairy science. 2023 Oct;106(10):7131-7146. [Content Brief]
- [4]. Erion MD, et al. MB06322 (CS-917): A potent and selective inhibitor of fructose 1,6-bisphosphatase for controlling gluconeogenesis in type 2 diabetes. Proceedings of the National Academy of Sciences of the United States of America. 2005 May 31;102(22):7970-5. [Content Brief]
- [5]. Li P, et al. 1α,25(OH)2D3 ameliorates insulin resistance by alleviating γδ T cell inflammation via enhancing fructose-1,6-bisphosphatase 1 expression. Theranostics. 2023 Sep 25;13(15):5290-5304. [Content Brief]
Keywords
