Managlinat dialanetil
Based on 1 Customer Validation
Managlinat dialanetil (MB06322) is an orally bioavailable inhibitor of fructose 1,6-bisphosphatase (FBPase) for the treatment of type 2 diabetes .
For research use only. We do not sell to patients.
- Purity: 99.67%
- CAS No.: 280782-97-0
- Formula: C21H33N4O6PS
- Molecular Weight:500.55
-
Storage:
-20°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| Hepatocyte | IC50 |
10 μM
Compound: 2, CS-917
|
Antidiabetic activity in monkey hepatocytes assessed as inhibition of glucose production after 4 hrs
Antidiabetic activity in monkey hepatocytes assessed as inhibition of glucose production after 4 hrs
|
[PMID: 20542703] |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
-
CAS No. 280782-97-0
-
Appearance Solid
-
Molecular Weight 500.55
-
Formula C21H33N4O6PS
-
Color White to yellow
-
SMILES
CC(C)CC(S1)=C(C(O2)=CC=C2[P](N[C@@H](C)C(OCC)=O)(N[C@@H](C)C(OCC)=O)=O)N=C1N
-
Synonyms
MB06322; CS-917
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
-20°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Solvent & Solubility
DMSO : 25 mg/mL (49.95 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
-
Data Sheet (273 KB)
-
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Portuguese - PT (252 KB)
-
Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.9978 mL | 9.9890 mL | 19.9780 mL | 49.9451 mL |
| 5 mM | 0.3996 mL | 1.9978 mL | 3.9956 mL | 9.9890 mL | |
| 10 mM | 0.1998 mL | 0.9989 mL | 1.9978 mL | 4.9945 mL | |
| 15 mM | 0.1332 mL | 0.6659 mL | 1.3319 mL | 3.3297 mL | |
| 20 mM | 0.0999 mL | 0.4995 mL | 0.9989 mL | 2.4973 mL | |
| 25 mM | 0.0799 mL | 0.3996 mL | 0.7991 mL | 1.9978 mL | |
| 30 mM | 0.0666 mL | 0.3330 mL | 0.6659 mL | 1.6648 mL | |
| 40 mM | 0.0499 mL | 0.2497 mL | 0.4995 mL | 1.2486 mL |
Powered by Bioz