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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
348 Results for "
thyroid
" in MedChemExpress (MCE) Product Catalog:
Products (348)
348 Results for "thyroid" in MCE Product Catalog:
63
63 Publications Verification
Synonyms: EGCG; Epigallocatechol Gallate
Category:
Anti-aging Plants Endogenous metabolite other families Flavonoids Flavonones Phenols Polyphenols Disease Research Fields Inflammation/Immunology Cancer
Target:
44
44 Cited Publications
Synonyms: Triiodothyronine; 3,3',5-Triiodo-L-thyronine; T3
44
44 Cited Publications
Synonyms: Triiodothyronine sodium; 3,3',5-Triiodo-L-thyronine sodium; T3 sodium
44
44 Cited Publications
Art. -Nr.: HY-A0070B
CAS. Nr.: 345957-19-9
Synonyms: Triiodothyronine sodium hydrate; 3,3',5-Triiodo-L-thyronine sodium hydrate; T3 sodium hydrate
25
25 Cited Publications
Target:
Forschungsgebiete:
Cardiovascular Disease Neurological Disease Endocrinology Cancer
IU1 is a selective, reversible USP14 inhibitor with an IC50 of 4-5 μM. IU1 binds USP14’s catalytic cleft to block deubiquitinase activity. IU1 induces calpain-dependent Tau cleavage, causes ATP deficits, reduces E1~Ub thioester levels and 26S proteasome assembly. IU1 enhances 26S proteasome chymotrypsin-like activity, modulates LC3B-dependent autophagy flux, reduces cancer cell proliferation and migration, and blocks G0/G1 to S phase cell cycle transition in follicular thyroid cancer cells. IU1 activates autophagy-lysosomal and ubiquitin-proteasome pathways, triggers apoptosis, and reduces cervical cancer cell growth. IU1 enhances degradation of proteasome substrates linked to neurodegenerative disease, accelerates oxidized protein degradation, and increases oxidative stress resistance. IU1 can be used for the research of Alzheimer’s disease, follicular thyroid cancer, ischemic stroke, cervical cancer, and neurodegenerative disease .
23
23 Cited Publications
Synonyms: MGL-3196; VIA-3196
Target:
Forschungsgebiete:
Resmetirom (MGL-3196) is a highly selective and orally active thyroid hormone receptor β (THR-β) agonist with an EC50 value of 0.21 μM. Resmetirom can be used for the study of noncirrhotic nonalcoholic steatohepatitis .
19
19 Cited Publications
Synonyms: Matridin-15-one; Vegard; α-Matrine
14
13
13 Cited Publications
Synonyms: Levothyroxine sodium; T4 sodium
13
13 Cited Publications
Art. -Nr.: HY-N6791
CAS. Nr.: 126643-37-6
Target:
Forschungsgebiete:
KT5823, a selective the cGMP-dependent protein kinase (PKG) inhibitor with an Ki value of 0.23 μM, it also inhibits PKA and PKC with Ki values of 10 μM and 4 μM, respectively. KT5823 is a Staurosporine-related protein kinase inhibitor, increases thyroid-stimulating hormone-induced (Na +/I - symporter) NIS expression, and iodide uptake in thyroid cells. KT5823 arrests cells after the G0/G1 boundary and causes increases in the levels of apoptotic DNA fragmentation .
13
13 Cited Publications
Synonyms: Sodium levothyroxine pentahydrate
12
7
7 Cited Publications
Synonyms: GC-1; QRX-431
Target:
Forschungsgebiete:
Sobetirome (GC-1) is a thyroid hormone receptor β (TRβ)-specific agonist which bind selectively to TRβ-1 with an EC50 of 0.16 μM .
6
6 Cited Publications
Synonyms: Ribonuclease A; EC 4.6.1.18; RNase A
Target:
Forschungsgebiete:
RNase A (Bovine pancreatic RNase) is a widely used Endonuclease in DNA purification by specifically hydrolyzing cytosine or uracil residues of RNA. RNase A degrades the RNA in the RNA/DNA duplex. RNase A catalyses the breakdown of 3',5'-phosphodiester linkages of single stranded RNA. RNase A family members in organisms are tightly involved in various physiological and pathological processes including cell growth and development, proliferation, differentiation and migration. Dysregulation of RNase A activity or expression level is closely related to pancreatic, ovarian, bladder and thyroid cancer. RNase A has tumor cell-killing ability .
5
5 Cited Publications
Target:
Forschungsgebiete:
8-Azaadenosine is a potent ADAR1 inhibitor and an A-to-I editing inhibitor. 8-Azaadenosine blocks RNA editing and inhibits proliferation, 3D growth, invasion, and migration in thyroid cancer cells .
5
5 Cited Publications
Synonyms: T4 Sulfate
5
5 Cited Publications
Target:
Forschungsgebiete:
NH-3 is an orally active, reversible thyroid hormone receptor (THR) antagonist with an IC50 of 55 nM. NH-3, a derivative of the selective thyromi-metic GC-1, inhibits binding of thyroid hormones to their receptor and that inhibits cofactor recruitment . NH-3 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
4
Category:
Target:
4
4 Cited Publications
Art. -Nr.: HY-P0002
CAS. Nr.: 24305-27-9
Synonyms: Thyrotropin-releasing-hormone; TRH
4
4 Cited Publications
Art. -Nr.: HY-P0002A
CAS. Nr.: 120876-23-5
Synonyms: Thyrotropin-releasing-hormone acetate; TRH acetate
Target:
Forschungsgebiete:
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
