TLR7 agonist 29
TLR7 agonist 29 (Compound 1) is the agonist for TLR7 with an EC50 of 5.2 nM for human TLR7 (EC50 for mouse TLR7 is 48.2 nM). TLR7 agonist 29 activates bone marrow-derived macrophages (BMDMs), stimulates myeloid cells in the tumor microenvironment, promotes the expression of PD-L1, CD86 and IFN-α. TLR7 agonist 29 can be used as payload for synthesis of ADC.
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- CAS. Nr.: 2275612-76-3
- Formel: C20H27N7O2
- Molecular Weight:397.47
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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human TLR7 5.2 nM (EC50) |
mTLR7 48.2 nM (EC50) |
Chemical Information
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CAS. Nr. 2275612-76-3
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Molecular Weight 397.47
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Formel C20H27N7O2
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SMILES
NC1=C2C(N(CC3=CN=C(CNC4CCC4)C=C3)C(O)=N2)=NC(OCCCC)=N1
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
TLR7 agonist 29 Related Classifications
HY-173070 Related Classifications
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