Isovaleramide
Based on 1 publication(s) in Google Scholar
Isovaleramide (3-Methylbutanamide) is an orally active anticonvulsant. Isovaleramide inhibits alcohol dehydrogenase (ADH) activity and regulates GABAergic system. Isovaleramide reduces acute kidney injury. Isovaleramide has antiepileptic, anxiolytic, sedative and hypnotic effects[1].
For research use only. We do not sell to patients.
- Purity: 98.0%
- CAS No.: 541-46-8
- Formula: C5H11NO
- Molecular Weight:101.15
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) Isovaleramide
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Biological Activity
Isovaleramide (10 and 20 mg/kg, i.v.,every 12 h for 48 h) reduces the mortality rate, attenuates the pathological damage of kidney tissues in EG-poisoned rats and down-regulates the expression of serum biomarkers of AKI[2].
Isovaleramide (100 mg/kg; p.o.) shows a 90% index protection against the maximal electroshock (MES)-induced seizure in mice, comparable to Sodium phenytoin (HY-B0448A)[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:ICR mice with electric shock induced seizures[1]
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Dosage:100 mg/kg
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Administration:p.o., a single dose at 4-hour following fasting
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Result:Evidenced a 90% index protection against the maximal electroshock seizure in mice.
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Animal Model:Rat model of EG poisoning[1]
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Dosage:10 and 20 mg/kg
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Administration:i.v.,every 12 h for 48 h
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Result:Effectively reduced the mortality of EG-poisoned rats, and this effect may be dose-dependent.
Chemical Information
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CAS No. 541-46-8
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Appearance Solid
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Molecular Weight 101.15
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Formula C5H11NO
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Color White to off-white
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SMILES
CC(C)CC(N)=O
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Synonyms
3-Methylbutanamide
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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Acta Physiol
Sodium-Coupled Monocarboxylate Absorption in the Airway Epithelium Is Facilitated by the SLC5A8 Co-Transporter. [Abstract]2025 Jun;241(6):e70051. PMID: 40326639
Solvent & Solubility
DMSO : 250 mg/mL (2471.58 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.08 mg/mL (20.56 mM); Clear solution
This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.08 mg/mL (20.56 mM); Clear solution
This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (272 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 9.8863 mL | 49.4315 mL | 98.8631 mL | 247.1577 mL |
| 5 mM | 1.9773 mL | 9.8863 mL | 19.7726 mL | 49.4315 mL | |
| 10 mM | 0.9886 mL | 4.9432 mL | 9.8863 mL | 24.7158 mL | |
| 15 mM | 0.6591 mL | 3.2954 mL | 6.5909 mL | 16.4772 mL | |
| 20 mM | 0.4943 mL | 2.4716 mL | 4.9432 mL | 12.3579 mL | |
| 25 mM | 0.3955 mL | 1.9773 mL | 3.9545 mL | 9.8863 mL | |
| 30 mM | 0.3295 mL | 1.6477 mL | 3.2954 mL | 8.2386 mL | |
| 40 mM | 0.2472 mL | 1.2358 mL | 2.4716 mL | 6.1789 mL | |
| 50 mM | 0.1977 mL | 0.9886 mL | 1.9773 mL | 4.9432 mL | |
| 60 mM | 0.1648 mL | 0.8239 mL | 1.6477 mL | 4.1193 mL | |
| 80 mM | 0.1236 mL | 0.6179 mL | 1.2358 mL | 3.0895 mL | |
| 100 mM | 0.0989 mL | 0.4943 mL | 0.9886 mL | 2.4716 mL |
Isovaleramide Related Classifications
HY-B1229 Related Classifications
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