L-Tryptophan-d5
Based on 3 publication(s) in Google Scholar
L-Tryptophan-d5 is the deuterium labeled L-Tryptophan. L-Tryptophan (Tryptophan) is an essential amino acid that is the precursor of serotonin, melatonin, and vitamin B3.
For research use only. We do not sell to patients.
- Purity: 99.86%
- CAS No.: 62595-11-3
- Formula: C11H7D5N2O2
- Molecular Weight:209.26
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Storage:
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) L-Tryptophan-d5
MoreAll Endogenous Metabolite Isoforms
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Biological Activity
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 62595-11-3
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Unlabeled Cas 73-22-3
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Appearance Solid
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Molecular Weight 209.26
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Formula C11H7D5N2O2
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Color Yellow to orange
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SMILES
OC([C@@H](N)CC1=C([2H])NC2=C([2H])C([2H])=C([2H])C([2H])=C12)=O
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Synonyms
Tryptophan-d5; Tryptophane-d5
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Publications (3)
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Journal Impact Factor
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Most Recent
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Redox Biol
Reprogramming of the kynurenine pathway impairs NAD+ homeostasis and mediates doxorubicin-induced cardiotoxicity in mice. [Abstract]2026 Feb:89:103957. PMID: 41389767 -
Food Res Int
Microbial interaction and metabolic profile of low-salinity doubanjiang fermentation with Staphylococcus carnosus and Zygosaccharomyces rouxii. [Abstract]2026 Jul 31:236:119248. PMID: 42116495 -
Food Res Int
Changing trends of non-volatile metabolites during industrial broad bean paste production via untargeted metabolomics. [Abstract]2026 Jan;223(Pt 1):117926. PMID: 41352829
Solvent & Solubility
DMSO : ≥ 33.33 mg/mL (159.28 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (276 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
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Handling Instructions (2659 KB)
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
[2]. Slominski A, et al. Conversion of L-tryptophan to serotonin and melatonin in human melanoma cells. FEBS Lett. 2002 Jan 30;511(1-3):102-6. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.7787 mL | 23.8937 mL | 47.7874 mL | 119.4686 mL |
| 5 mM | 0.9557 mL | 4.7787 mL | 9.5575 mL | 23.8937 mL | |
| 10 mM | 0.4779 mL | 2.3894 mL | 4.7787 mL | 11.9469 mL | |
| 15 mM | 0.3186 mL | 1.5929 mL | 3.1858 mL | 7.9646 mL | |
| 20 mM | 0.2389 mL | 1.1947 mL | 2.3894 mL | 5.9734 mL | |
| 25 mM | 0.1911 mL | 0.9557 mL | 1.9115 mL | 4.7787 mL | |
| 30 mM | 0.1593 mL | 0.7965 mL | 1.5929 mL | 3.9823 mL | |
| 40 mM | 0.1195 mL | 0.5973 mL | 1.1947 mL | 2.9867 mL | |
| 50 mM | 0.0956 mL | 0.4779 mL | 0.9557 mL | 2.3894 mL | |
| 60 mM | 0.0796 mL | 0.3982 mL | 0.7965 mL | 1.9911 mL | |
| 80 mM | 0.0597 mL | 0.2987 mL | 0.5973 mL | 1.4934 mL | |
| 100 mM | 0.0478 mL | 0.2389 mL | 0.4779 mL | 1.1947 mL |
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