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Cat. No.: HY-106306

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Laprafylline

(Synonyms: S 9795)

Laprafylline (S 9795), a xanthine derivative, is a bronchodilator. Laprafylline has potent anti-bronchoconstrictive effects, inhibiting action on mast cell degranulation and phosphodiesterase (PDE) activity (IC₅₀ of 6 μM).

For research use only. We do not sell to patients.

CAS No.: 90749-32-9
Formula: C₂₉H₃₆N₆O₂
Molecular Weight:500.64

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

Laprafylline Chemical Structure

CAS No.: 90749-32-9

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

All Phosphodiesterase (PDE) Isoforms :

In Vivo

In male Sprague Dawley rats, Laprafylline (S 9795; 2.5-10mg/kg; iv) disappears rapidly from plasma with an elimination t_1/2 of 0.8 h, regardless of the dose administered. The volume of distribution is high (about 3 L/kg) but total clearance is also high (about 40 mL/min/kg).

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 90749-32-9
Molecular Weight 500.64
Formula C₂₉H₃₆N₆O₂
SMILES

CC(C)CN1C2=C(C(N(C)C1=O)=O)N=C(CCN3CCN(C(C4=CC=CC=C4)C5=CC=CC=C5)CC3)N2
Synonyms

S 9795
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. G Bianchi, et al. Kinetics and brain uptake of S 9795, a new xanthine derivate, in rats. Eur J Drug Metab Pharmacokinet. 1989 Jul-Sep;14(3):201-8. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
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Laprafylline

All Phosphodiesterase (PDE) Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Laprafylline Related Classifications

HY-106306 Related Classifications