MAO-B-IN-53
MAO-B-IN-53 is a human monoamine oxidase B (hMAO-B) inhibitor with an IC50 of 0.066 μM. MAO-B-IN-53 exhibits mixed reversible inhibition, binds stably to the hMAO-B active site, and shows high selectivity over hMAO-A. MAO-B-IN-53 acts as a neuroprotective agent, protects against 6-OHDA-induced damage, and exhibits low neurotoxicity in neuroblastoma cells. MAO-B-IN-53 can be used for the research of Parkinson's disease.
For research use only. We do not sell to patients.
- CAS No.: 3069131-62-7
- Formula: C20H19F2NO
- Molecular Weight:327.37
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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- References
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Help & FAQs
Biological Activity
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hMAO-B 66 nM (IC50) |
MAO-B-IN-53 (Compound 8) (1.25-10 μM; 24 h) exhibits low cytotoxicity against SH-SY5Y cells, with a cell viability of ≥86.5% even at the concentration up to 10 μM after 24 h of incubation[1].
MAO-B-IN-53 (1.25-5 μM; 25 h) exerts significant neuroprotective effects against 6-OHDA-induced injury in SH-SY5Y cells, with the maximum cell survival rate reaching 70.0% at 1.25 μM[1].
MAO-B-IN-53 (1.25-2.5 μM; 24 h) exerts in vitro antioxidant activity, at concentrations up to 2.5 μM, it does not increase intracellular ROS levels in SH-SY5Y cells or induce oxidative damage[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 3069131-62-7
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Molecular Weight 327.37
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Formula C20H19F2NO
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SMILES
C#CCNC1CCCC2=C1C=CC(OCC3=CC=C(F)C(F)=C3)=C2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
MAO-B-IN-53 Related Classifications
HY-181268 Related Classifications
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