3069131-62-7
3069131-62-7
Chemical Structure
MAO-B-IN-53
- CAS No.: 3069131-62-7
- Formula:C20H19F2NO
- Molecular Weight:327.37
InChIKey: NXYNXFYUHJTHOB-UHFFFAOYSA-N
SMILES: C#CCNC1CCCC2=C1C=CC(OCC3=CC=C(F)C(F)=C3)=C2
Biological Activity: MAO-B-IN-53 is a human monoamine oxidase B (hMAO-B) inhibitor with an IC50 of 0.066 μM. MAO-B-IN-53 exhibits mixed reversible inhibition, binds stably to the hMAO-B active site, and shows high selectivity over hMAO-A. MAO-B-IN-53 acts as a neuroprotective agent, protects against 6-OHDA-induced damage, and exhibits low neurotoxicity in neuroblastoma cells. MAO-B-IN-53 can be used for the research of Parkinson's disease[1].
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MAO-B-IN-53 | MAO-B-IN-53 is a human monoamine oxidase B (hMAO-B) inhibitor with an IC50 of 0.066 μM. MAO-B-IN-53 exhibits mixed reversible inhibition, binds stably to the hMAO-B active site, and shows high selectivity over hMAO-A. MAO-B-IN-53 acts as a neuroprotective agent, protects against 6-OHDA-induced damage, and exhibits low neurotoxicity in neuroblastoma cells. MAO-B-IN-53 can be used for the research of Parkinson's disease. | |||||||||||||||||||||
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