RGD peptide (GRGDNP) TFA
Based on 7 publication(s) in Google Scholar
RGD peptide (GRGDNP) TFA is an inhibitor of integrin-ligand interactions. RGD peptide (GRGDNP) TFA competitively inhibits α5β1 binding with extracellular matrice (ECM). RGD peptide (GRGDNP) TFA promotes apoptosis through activation of conformation changes that enhance pro-caspase-3 activation and autoprocessing. RGD peptide (GRGDNP) TFA plays an important role in cell adhesion, migration, growth, and differentiation.
For research use only. We do not sell to patients.
- Purity: 99.94%
- Formula: C25H39F3N10O12
- Molecular Weight:728.63
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Storage:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) RGD peptide (GRGDNP) TFA
More- Adv Mater. 2024 Jul 18:e2406140. [Abstract]
- Nat Biomed Eng. 2025 Nov 3. [Abstract]
- Cell Death Dis. 2022 Jul 1;13(7):577. [Abstract]
- Biofabrication. 2021 Apr 26;13(3). [Abstract]
- Biomacromolecules. 2023 Apr 10;24(4):1574-1584. [Abstract]
- J Cell Sci. 2025 Dec 1;138(23):jcs264412. [Abstract]
- bioRxiv. 2024 October 06.
Customer Validation & Images
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Bio/Physico-chemical Assay
Biological Activity
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α5β1 |
RGD peptide (GRGDNP) TFA (50 μM ; preincubation for 3 hours before stretch) abolishes stretch-induced IKK activation and IL-6 mRNA expression. It shows little effect on the IKK activity and IL-6 mRNA expression in unstretched HUVECs[2].
RGD peptide (GRGDNP) TFA (300 μg/mL; for 6 hours) completely reverses enhanced FN1 expression in oxygen glucose deprivation(OGD) treated primary hippocampal neurons, HT22 cell lines and in its sEVs[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Gly-Arg-Gly-Asp-Asn-Pro
GRGDNP
Chemical Information
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Appearance Solid
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Molecular Weight 728.63
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Formula C25H39F3N10O12
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Color White to off-white
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (7)
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Journal Impact Factor
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Most Recent
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Adv Mater
2024 Jul 18:e2406140. PMID: 39023382
RGD peptide (GRGDNP) TFA purchased from MedChemExpress. Usage Cited in: Adv Mater. 2024 Jul 18:e2406140. [Abstract]
Comparison of the adhesion of B-GEM and R-GEM cells to 4T1 tumor cells after 10 min of coincubation in medium preadded with free RGD peptide (0-8 μM). Exogenous free RGD dose-dependently reversed the increase in adhesion of R-GEM cells to tumor cells.
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Nat Biomed Eng
Nonexpansive biodegradable matrix promotes blood vessel organoid development for neurovascular repair and functional recovery in ischaemic stroke. [Abstract]2025 Nov 3. PMID: 41184604 -
Cell Death Dis
The kinase activity of integrin-linked kinase regulates cellular senescence in gastric cancer. [Abstract]2022 Jul 1;13(7):577. PMID: 35778385 -
Biofabrication
A novel 4D cell culture mimicking stomach peristalsis altered gastric cancer spheroids growth and malignance. [Abstract]2021 Apr 26;13(3). PMID: 33836517 -
Biomacromolecules
2023 Apr 10;24(4):1574-1584. PMID: 36943688 -
J Cell Sci
Bile canaliculi formation in primary hepatocytes requires α1β1 integrin-dependent adherens junction re-organization. [Abstract]2025 Dec 1;138(23):jcs264412. PMID: 41347643 -
Solvent & Solubility
DMSO : ≥ 50 mg/mL (68.62 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : ≥ 50 mg/mL (68.62 mM)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 100 mg/mL (137.24 mM); Clear solution; Need ultrasonic
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
Purity & Documentation
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Data Sheet (279 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. C D Buckley, et al. RGD peptides induce apoptosis by direct caspase-3 activation. Nature. 1999 Feb 11;397(6719):534-9. [Content Brief]
[2]. Wei Xia, et al. Damaged brain accelerates bone healing by releasing small extracellular vesicles that target osteoprogenitors. Nat Commun. 2021 Oct 15;12(1):6043. [Content Brief]
[3]. Akitoshi Sasamoto, et al. Mechanotransduction by integrin is essential for IL-6 secretion from endothelial cells in response to uniaxial continuous stretch. Am J Physiol Cell Physiol. 2005 May;288(5):C1012-22. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO / H2O | 1 mM | 1.3724 mL | 6.8622 mL | 13.7244 mL | 34.3110 mL |
| 5 mM | 0.2745 mL | 1.3724 mL | 2.7449 mL | 6.8622 mL | |
| 10 mM | 0.1372 mL | 0.6862 mL | 1.3724 mL | 3.4311 mL | |
| 15 mM | 0.0915 mL | 0.4575 mL | 0.9150 mL | 2.2874 mL | |
| 20 mM | 0.0686 mL | 0.3431 mL | 0.6862 mL | 1.7155 mL | |
| 25 mM | 0.0549 mL | 0.2745 mL | 0.5490 mL | 1.3724 mL | |
| 30 mM | 0.0457 mL | 0.2287 mL | 0.4575 mL | 1.1437 mL | |
| 40 mM | 0.0343 mL | 0.1716 mL | 0.3431 mL | 0.8578 mL | |
| 50 mM | 0.0274 mL | 0.1372 mL | 0.2745 mL | 0.6862 mL | |
| 60 mM | 0.0229 mL | 0.1144 mL | 0.2287 mL | 0.5718 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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