Nintedanib-d3
Based on 1 Customer Validation
Nintedanib-d3 is the deuterium labeled Nintedanib. Nintedanib (BIBF 1120) is a potent triple angiokinase inhibitor for VEGFR1/2/3, FGFR1/2/3 and PDGFRα/β with IC50s of 34 nM/13 nM/13 nM, 69 nM/37 nM/108 nM and 59 nM/65 nM, respectively.
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- CAS No.: 1624587-84-3
- Formule: C31H30D3N5O4
- Masse moléculaire:542.64
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Stockage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 1624587-84-3
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Unlabeled Cas 656247-17-5
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Appearance Solid
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Masse moléculaire 542.64
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Formule C31H30D3N5O4
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SMILES
O=C(C1=CC(NC/2=O)=C(C=C1)C2=C(NC3=CC=C(N(C)C(CN4CCN(C([2H])([2H])[2H])CC4)=O)C=C3)/C5=CC=CC=C5)OC
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Synonyms
BIBF 1120-d3
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvant et solubilité
DMSO : 100 mg/mL (184.28 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
Références
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
[2]. Hilberg F, et al. BIBF 1120: triple angiokinase inhibitor with sustained receptor blockade and good antitumor efficacy. Cancer Res, 2008, 68(12), 4774-4782. [Content Brief]
[3]. Roth GJ, et al. Design, synthesis, and evaluation of indolinones as triple angiokinase inhibitors and the discovery of a highly specific 6-methoxycarbonyl-substituted indolinone (BIBF 1120). J Med Chem, 2009, 52(14), 4466-4480. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.8428 mL | 9.2142 mL | 18.4284 mL | 46.0711 mL |
| 5 mM | 0.3686 mL | 1.8428 mL | 3.6857 mL | 9.2142 mL | |
| 10 mM | 0.1843 mL | 0.9214 mL | 1.8428 mL | 4.6071 mL | |
| 15 mM | 0.1229 mL | 0.6143 mL | 1.2286 mL | 3.0714 mL | |
| 20 mM | 0.0921 mL | 0.4607 mL | 0.9214 mL | 2.3036 mL | |
| 25 mM | 0.0737 mL | 0.3686 mL | 0.7371 mL | 1.8428 mL | |
| 30 mM | 0.0614 mL | 0.3071 mL | 0.6143 mL | 1.5357 mL | |
| 40 mM | 0.0461 mL | 0.2304 mL | 0.4607 mL | 1.1518 mL | |
| 50 mM | 0.0369 mL | 0.1843 mL | 0.3686 mL | 0.9214 mL | |
| 60 mM | 0.0307 mL | 0.1536 mL | 0.3071 mL | 0.7679 mL | |
| 80 mM | 0.0230 mL | 0.1152 mL | 0.2304 mL | 0.5759 mL | |
| 100 mM | 0.0184 mL | 0.0921 mL | 0.1843 mL | 0.4607 mL |
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