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Cat. No.: HY-184007

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PROTAC BCL6 Degrader-4

PROTAC BCL6 Degrader-4 is a potent PROTAC BCL6 degrader. PROTAC BCL6 Degrader-4 recruits CRBN E3 ligase machinery to promote ubiquitination and proteasomal degradation of BCL6. PROTAC BCL6 Degrader-4 can be used for the research of diffuse large B-cell lymphoma and related hematological malignancies.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

CAS No.: 3121287-19-9
Formule: C₄₇H₅₁ClF₂N₁₀O₆
Masse moléculaire:925.42

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Please store the product under the recommended conditions in the Certificate of Analysis.

PROTAC BCL6 Degrader-4 Chemical Structure

CAS No.: 3121287-19-9

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
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Activité biologique

Description

Voir tous les produits spécifiques à Isoform PROTACs :

In Vitro

PROTAC BCL6 Degrader-4 (compound 12) potently degrades BCL6 in T47D cells with a DC₅₀ of <5 nM and achieves ≥70% maximum degradation^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 3121287-19-9
Masse moléculaire 925.42
Formule C₄₇H₅₁ClF₂N₁₀O₆
SMILES

CN1C(C2=C(C3=C1C=CC(NC4=NC(N5CCC(CC5)O[C@H]6C[C@@H](C6)N7CCC(CC7)C8=CC9=C(C(N(N=C9)C%10CCC(NC%10=O)=O)=O)C=C8)=NC=C4Cl)=C3)N[C@H](C(F)(CO2)F)C%11CC%11)=O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Renner AC, et al. Degradation and Detection: Integrating BCL6 Targeted Protein Degradation with Biomarker-Guided BET Inhibition in Cancer. ACS Med Chem Lett. 2026 May 26;17(6):1246-1248. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Activité biologique
- Description
- In Vitro
Chemical Information
Pureté et documentation
Références

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PROTAC BCL6 Degrader-4

Voir tous les produits spécifiques à Isoform PROTACs