2. Metabolic Enzyme/Protease
  3. Aldehyde Dehydrogenase (ALDH)
  4. CM037

CM037 is a highly selective and competitive ALDH1A1 inhibitor (IC50=4.6 μM). CM037 blocks the catalytic activity of ALDH1A1, thereby inhibiting the activation of the downstream HIF-1α/VEGF pathway. CM037 is mainly used to study the ALDH1A1-mediated regulation of cancer stem cells (CSCs) and angiogenesis, especially in breast cancer, showing the potential to inhibit tumor angiogenesis and stem cell characteristics.

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CM037

CM037 構造式

CAS 番号 : 896795-60-1

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 110 在庫あり
Solution
10 mM * 1 mL in DMSO USD 110 在庫あり
Solid
5 mg $100 在庫あり
10 mg $160 在庫あり
25 mg $320 在庫あり
50 mg   お問い合わせ  
100 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

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Based on 1 publication(s) in Google Scholar

CM037 関連抗体

Top Publications Citing Use of Products

Aldehyde Dehydrogenase (ALDH) アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
ALDH1 ALDH2 ALDH3

  • 生物活性

  • 純度とドキュメンテーション

  • 参考文献

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製品説明

CM037 is a highly selective and competitive ALDH1A1 inhibitor (IC50=4.6 μM). CM037 blocks the catalytic activity of ALDH1A1, thereby inhibiting the activation of the downstream HIF-1α/VEGF pathway. CM037 is mainly used to study the ALDH1A1-mediated regulation of cancer stem cells (CSCs) and angiogenesis, especially in breast cancer, showing the potential to inhibit tumor angiogenesis and stem cell characteristics[1][2].

IC50 & Target

ALDH1

 

Cellular Effect
Cell Line Type Value Description References
OV-90 EC50
3.96 μM
Compound: 2
Cytotoxicity against 3D culture of human OV90 cells assessed as decrease in cell viability after 6 days by CellTiter-Glo assay
Cytotoxicity against 3D culture of human OV90 cells assessed as decrease in cell viability after 6 days by CellTiter-Glo assay
[PMID: 29767973]
体外実験

Cell viability and VEGF release experiments: CM037 (10 μM; 18 h) dose-dependently downregulates the expression and secretion of VEGF in MCF-7 cells and inhibited the proliferation and migration of endothelial cells[2].
Western blot experiment: CM037 (1 μM, 10 μM; 18 h) significantly reduces the levels of HIF-1α and VEGF proteins and blocked the RA/RAR signaling pathway[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CM037 関連抗体

Cell Viability Assay[1]

Cell Line: MCF-7 breast cancer cells
Concentration: 1-10 μM
Incubation Time: 18-48 h
Result: Dose-dependently reduced VEGF secretion (ELISA) and HIF-1α expression (WB) in MCF-7 cells, without significant cytotoxicity (MTT assay).

Western Blot Analysis[1]

Cell Line: MCF-7 cells
Concentration: 1 μM
Incubation Time: 48 h
Result: Decreased phosphorylated RARα and HIF-1α protein levels, concurrent with reduced VEGF expression, indicating inhibition of RA/RAR-mediated angiogenic signaling.
分子量

431.57

分子式

C21H25N3O3S2
CAS 番号
Appearance

Solid

Color

Light brown to brown

SMILES

O=C1C2=C(N=C(SCC(OCC)=O)N1CCCN3CCCC3)C4=CC=CC=C4S2
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

DMSO : 83.33 mg/mL (193.09 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3171 mL 11.5856 mL 23.1712 mL
5 mM 0.4634 mL 2.3171 mL 4.6342 mL
10 mM 0.2317 mL 1.1586 mL 2.3171 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

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体積 （開始）

V1

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濃度 （終了）

C2

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体積 （終了）

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Calculation results:
Working solution concentration: mg/mL
純度とドキュメンテーション

純度: 99.55%

COA (249 KB) HNMR (265 KB) LCMS (94 KB)

取扱説明書 (2659 KB)
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.3171 mL 11.5856 mL 23.1712 mL 57.9280 mL
5 mM 0.4634 mL 2.3171 mL 4.6342 mL 11.5856 mL
10 mM 0.2317 mL 1.1586 mL 2.3171 mL 5.7928 mL
15 mM 0.1545 mL 0.7724 mL 1.5447 mL 3.8619 mL
20 mM 0.1159 mL 0.5793 mL 1.1586 mL 2.8964 mL
25 mM 0.0927 mL 0.4634 mL 0.9268 mL 2.3171 mL
30 mM 0.0772 mL 0.3862 mL 0.7724 mL 1.9309 mL
40 mM 0.0579 mL 0.2896 mL 0.5793 mL 1.4482 mL
50 mM 0.0463 mL 0.2317 mL 0.4634 mL 1.1586 mL
60 mM 0.0386 mL 0.1931 mL 0.3862 mL 0.9655 mL
80 mM 0.0290 mL 0.1448 mL 0.2896 mL 0.7241 mL
100 mM 0.0232 mL 0.1159 mL 0.2317 mL 0.5793 mL
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CM037 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CM037896795-60-1A37CM 037CM-037A 37A-37Aldehyde Dehydrogenase (ALDH)Inhibitorinhibitorinhibit

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製品名:
CM037
製品番号:
HY-110294
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