2. Metabolic Enzyme/Protease
  3. Aldehyde Dehydrogenase (ALDH)
  4. MCI-INI-3

MCI-INI-3 is a selective competitive inhibitor of human ALDH1A3 (with a Ki value of 0.55 μM for ALDH1A3 and a Ki value of 78.2 μM for ALDH1A1). MCIINI-3 inhibits the biosynthesis of retinoic acid and reduces the viability of GSC-83 and GSC-326 glioblastoma cells.

For research use only. We do not sell to patients.

MCI-INI-3

MCI-INI-3 Chemical Structure

CAS No. : 1011366-31-6

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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Based on 1 publication(s) in Google Scholar

MCI-INI-3 Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE MCI-INI-3

View All Aldehyde Dehydrogenase (ALDH) Isoform Specific Products:

View All Isoforms
ALDH1 ALDH2 ALDH3

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  • Purity & Documentation

  • References

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Description

MCI-INI-3 is a selective competitive inhibitor of human ALDH1A3 (with a Ki value of 0.55 μM for ALDH1A3 and a Ki value of 78.2 μM for ALDH1A1). MCIINI-3 inhibits the biosynthesis of retinoic acid and reduces the viability of GSC-83 and GSC-326 glioblastoma cells[1].

IC50 & Target

ALDH1A3

0.55 μM (Ki)

ALDH1A1

78.2 μM (Ki)

Molecular Weight

373.36

Formula

C21H15N3O4
CAS No.
Appearance

Solid

Color

Light yellow to green yellow

SMILES

O=C(C1=CC(C2=CC3=C(OCO3)C=C2)=NC4=CC(C5=CC=CC=C5)=NN41)OC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 6.67 mg/mL (17.86 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6784 mL 13.3919 mL 26.7838 mL
5 mM 0.5357 mL 2.6784 mL 5.3568 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.23%

SDS (251 KB)

COA (250 KB) HNMR (134 KB) RP-HPLC (234 KB) LCMS (391 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.6784 mL 13.3919 mL 26.7838 mL 66.9595 mL
5 mM 0.5357 mL 2.6784 mL 5.3568 mL 13.3919 mL
10 mM 0.2678 mL 1.3392 mL 2.6784 mL 6.6960 mL
15 mM 0.1786 mL 0.8928 mL 1.7856 mL 4.4640 mL
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MCI-INI-3 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MCI-INI-31011366-31-6Aldehyde Dehydrogenase (ALDH)selective competitive inhibitorGSC-83 and GSC-326 glioblastoma cellsInhibitorinhibitorinhibit

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