1011366-31-6
1011366-31-6
Chemical Structure
MCI-INI-3
- CAS No.: 1011366-31-6
- Formula:C21H15N3O4
- Molecular Weight:373.36
InChIKey: DCSWTUKGGUNNLU-UHFFFAOYSA-N
SMILES: O=C(C1=CC(C2=CC3=C(OCO3)C=C2)=NC4=CC(C5=CC=CC=C5)=NN41)OC
Biological Activity: MCI-INI-3 is a selective ALDH1A3 inhibitor, with an IC50 of 0.46 μM and a Ki of 0.55 μM against hALDH1A3. MCI-INI-3 inhibits retinoic acid (HY-14649) biosynthesis. MCI-INI-3 can be used in research related to glioblastoma and glioma[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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MCI-INI-3 | 99.23% | MCI-INI-3 is a selective ALDH1A3 inhibitor, with an IC50 of 0.46 μM and a Ki of 0.55 μM against hALDH1A3. MCI-INI-3 inhibits retinoic acid (HY-14649) biosynthesis. MCI-INI-3 can be used in research related to glioblastoma and glioma. | ||||||||||||||||||||
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References
- [1]. Li J, et al. A specific inhibitor of ALDH1A3 regulates retinoic acid biosynthesis in glioma stem cells. Communications biology. 2021 Dec 21;4(1):1420. [Content Brief]
- [2]. MacLean MR, et al. Informed by Cancer Stem Cells of Solid Tumors: Advances in Treatments Targeting Tumor-Promoting Factors and Pathways. International journal of molecular sciences. 2024 Apr 07;25(7):4102. [Content Brief]
Keywords
