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Cat. No.: HY-13837

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P4Q-391

P4Q-391 is a Plasmodium cytochrome bc1 complex inhibitor with antimalarial activity. P4Q-391 is promising for research of parasites.

For research use only. We do not sell to patients.

CAS No.: 1374758-06-1
Formula: C₂₄H₁₆ClF₄NO₄
Molecular Weight:493.83

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

P4Q-391 Chemical Structure

CAS No.: 1374758-06-1

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

P4Q-391 is a Plasmodium cytochrome bc1 complex inhibitor with antimalarial activity. P4Q-391 is promising for research of parasites^[1].

All Parasite Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
J774	EC₅₀	>20.2 μM Compound: 7, P4Q-391	Cytotoxicity against mouse J774 cells after 72 hrs by CellTiter 96 assay Cytotoxicity against mouse J774 cells after 72 hrs by CellTiter 96 assay	[PMID: 25148516]
J774	EC₅₀	20.2 μM Compound: 7, P4Q-391	Cytotoxicity against mouse J774 cells after 72 hrs by CellTiter 96 assay Cytotoxicity against mouse J774 cells after 72 hrs by CellTiter 96 assay	[PMID: 25148516]

Chemical Information

CAS No. 1374758-06-1
Molecular Weight 493.83
Formula C₂₄H₁₆ClF₄NO₄
SMILES

O=C1C(C2=CC=C(OC3=CC=C(OC(F)(F)F)C=C3)C=C2F)=C(C)NC4=C1C=C(Cl)C(OC)=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Cross RM, et al. Orally bioavailable 6-chloro-7-methoxy-4(1H)-quinolones efficacious against multiple stages of Plasmodium. J Med Chem. 2014 Nov 13;57(21):8860-79. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
Chemical Information
Purity & Documentation
References

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P4Q-391

All Parasite Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

P4Q-391 Related Classifications

HY-13837 Related Classifications