Grk2 - G protein-coupled receptor kinase 2 Gene

Also Known as Adrbk1; Bark-1; Adrbk-1; beta ARK; betaARK1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 110355

Summary

Enables G protein-coupled receptor kinase activity. Involved in negative regulation of relaxation of smooth muscle. Acts upstream of or within several processes, including desensitization of G protein-coupled receptor signaling pathway; protein phosphorylation; and regulation of the force of heart contraction. Located in membrane. Is expressed in several structures, including central nervous system; genitourinary system; heart; limb; and mesenchyme derived from neural crest. Orthologous to human GRK2 (G protein-coupled receptor kinase 2). [provided by Alliance of Genome Resources, Apr 2022]

Grk2 Products (2)

mRNA Protein Name
NM_001290818.1 NP_001277747.1 beta-adrenergic receptor kinase 1 isoform 1
NM_130863.2 NP_570933.1 beta-adrenergic receptor kinase 1 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables G protein-coupled receptor kinase activity IDA
IDA: Inferred from direct assay
1869533 MGI
enables G protein-coupled receptor kinase activity IMP
IMP: Inferred from mutant phenotype
8917529 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
15218143 MGI
enables protein kinase activity IDA
IDA: Inferred from direct assay
15218143 MGI
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
17544362 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
14712229 MGI
acts upstream of or within desensitization of G protein-coupled receptor signaling pathway IGI
IGI: Inferred from genetic interaction
7761854 MGI
acts upstream of or within desensitization of G protein-coupled receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
10338466 MGI
acts upstream of or within heart development IMP
IMP: Inferred from mutant phenotype
8917529 MGI
involved in negative regulation of relaxation of smooth muscle IMP
IMP: Inferred from mutant phenotype
30284927 MGI
acts upstream of or within peptidyl-serine phosphorylation IDA
IDA: Inferred from direct assay
17544362 MGI
acts upstream of or within peptidyl-threonine phosphorylation IDA
IDA: Inferred from direct assay
17544362 MGI
acts upstream of or within protein phosphorylation IDA
IDA: Inferred from direct assay
15218143 MGI
acts upstream of or within regulation of the force of heart contraction IGI
IGI: Inferred from genetic interaction
7761854 MGI
Cellular Component GO Annotation Evidence References Source
located in membrane IDA
IDA: Inferred from direct assay
15218143 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

beta-adrenergic receptor kinase 1

  • adrenergic receptor kinase, beta 1

  • beta-AR kinase-1

Related Agents

  • Approval
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B0492A Paroxetine hydrochloride hemihydrate Inhibitor 99.96% Unkown

Pre-clinical Phase

Bioactive Molecules (32)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-103045 CMPD101 Inhibitor 99.49% Unkown
HY-18991 CCG215022 Inhibitor 99.79% Unkown
HY-109562A CCG258208 hydrochloride 98.05% Unkown
HY-121983 CAY10594 Modulator 98.64% Unkown
HY-156863 GRK2 Inhibitor 2 Inhibitor 99.92% Unkown
HY-W013411A Locostatin Inhibitor 99.88% Unkown
HY-18990 GSK180736A Inhibitor 98.81% Unkown
HY-47573 CCG273441 Inhibitor 98.78% Unkown
HY-123538 GRK2 Inhibitor 1 Inhibitor 98.06% Unkown
HY-139690 CCG258747 Inhibitor 98.96% Unkown
HY-P1396A GRK2i TFA Inhibitor 99.89% Unkown
HY-177948 GRK2 degrader-1 Degrader 98.83% Unkown
HY-RS05813 GRK2 Human Pre-designed siRNA Set A Inhibitor / Unkown
HY-129118 Takeda103A Inhibitor 98.69% Unkown
HY-109562 CCG258208 Inhibitor / Unkown
HY-183057 GRK2 modulator 1 Modulator / Unkown
HY-179707 GRL-03022 Inhibitor / Unkown
HY-150022 GRK5-IN-4 Inhibitor / Unkown
HY-150039 CCG-271423 Inhibitor / Unkown
HY-P1396 GRK2i Inhibitor / Unkown
HY-103045A CMPD101 hydrochloride Inhibitor / Unkown
HY-155099 FGH31 / Unkown
HY-120168 CCG 258001 Inhibitor / Unkown
HY-B0492S1 Paroxetine-d4 hydrochloride Inhibitor 99.16% Unkown
HY-118046 GSK2163632A Inhibitor / Unkown
HY-119232 GSK466317A Inhibitor / Unkown
HY-123254 CCG-224406 Inhibitor / Unkown
HY-120718 CCG 224061 Inhibitor / Unkown
HY-168971 Paeoniflorin-6′-O-benzene sulfonate Inhibitor / Unkown
HY-RS16845 Grk2 Mouse Pre-designed siRNA Set A Inhibitor / Unkown
HY-RS23286 Grk2 Rat Pre-designed siRNA Set A Inhibitor / Unkown
HY-180583 GRK5-IN-5 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Grk2 NCBI NCBI:156