CCG 224061
CCG 224061 is a G protein-coupled receptor kinase 2 (GRK2) inhibitor with a IC50 of 0.066 μM. CCG 224061 inhibits GRK activity in cardiomyocytes. CCG 224061 is applicable to research related to heart disease, heart failure, myocardial hypertrophy and hypertension.
For research use only. We do not sell to patients.
- CAS No.: 2055990-82-2
- Formula: C19H20FN3O
- Molecular Weight:325.39
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
|
GRK2 0.066 μM (IC50) |
CCG 224061 (E18) potently and selectively inhibits GRK2 with an IC50 of 0.07 μM, while it shows weak inhibitory effects on GRK5 (IC50 12.8 μM) and GRK1 (IC50 65.7 μM)[1].
CCG 224061 (5 min) potently inhibits GRK2 (IC50 = 0.066 μM) and exhibits activity against GRK1 (IC50 = 6.4 μM), GRK5 (IC50 = 1.3 μM), PKA (IC50 = 3.1 μM) and ROCK1 (100% inhibition at 10 μM) in in vitro purified kinase assays[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| Species | Dose | Route | AUC0-∞ |
|---|---|---|---|
| Mice[2] | 10 mg/kg | i.p. | 731 ng·h/mL |
Chemical Information
-
CAS No. 2055990-82-2
-
Molecular Weight 325.39
-
Formula C19H20FN3O
-
SMILES
C(OC=1C=C2C(=CC1)NN=C2)[C@H]3[C@@H](CCNC3)C4=CC=C(F)C=C4
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Powered by Bioz