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Takeda103A is a potent inhibitor of GRK2. G protein-coupled receptors (GPCRs) are central to many physiological processes. Takeda103A has the potential for the research of heart failure.

For research use only. We do not sell to patients.

Takeda103A Chemical Structure

Takeda103A Chemical Structure

CAS No. : 865609-72-9

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5 mg USD 580 In-stock
10 mg USD 928 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

Takeda103A is a potent inhibitor of GRK2. G protein-coupled receptors (GPCRs) are central to many physiological processes. Takeda103A has the potential for the research of heart failure[1].

Molecular Weight

463.48

Formula

C24H23F2N7O
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(NCC1=C(F)C=CC=C1F)C2=CC=CC(NCC3=NN=C(C4=NC=NC=C4)N3CCC)=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (269.70 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1576 mL 10.7880 mL 21.5759 mL
5 mM 0.4315 mL 2.1576 mL 4.3152 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 98.69%

COA (247 KB) HNMR (271 KB) LCMS (97 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1576 mL 10.7880 mL 21.5759 mL 53.9398 mL
5 mM 0.4315 mL 2.1576 mL 4.3152 mL 10.7880 mL
10 mM 0.2158 mL 1.0788 mL 2.1576 mL 5.3940 mL
15 mM 0.1438 mL 0.7192 mL 1.4384 mL 3.5960 mL
20 mM 0.1079 mL 0.5394 mL 1.0788 mL 2.6970 mL
25 mM 0.0863 mL 0.4315 mL 0.8630 mL 2.1576 mL
30 mM 0.0719 mL 0.3596 mL 0.7192 mL 1.7980 mL
40 mM 0.0539 mL 0.2697 mL 0.5394 mL 1.3485 mL
50 mM 0.0432 mL 0.2158 mL 0.4315 mL 1.0788 mL
60 mM 0.0360 mL 0.1798 mL 0.3596 mL 0.8990 mL
80 mM 0.0270 mL 0.1348 mL 0.2697 mL 0.6742 mL
100 mM 0.0216 mL 0.1079 mL 0.2158 mL 0.5394 mL
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Takeda103A Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Takeda103A865609-72-9OthersGRK2GPCRsheart failureInhibitorinhibitorinhibit

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