3-O-Methyldopa
Based on 1 publication(s) in Google Scholar
3-O-Methyldopa (3-Methoxy-L-tyrosine) is a metabolite of L-DOPA (HY-N0304) that can cross the blood-brain barrier (BBB). 3-O-Methyldopa inhibits the astrocyte-mediated protective effect of L-DOPA (HY-N0304) on dopaminergic neurons. In addition, 3-O-Methyldopa has certain antidepressant and neuroprotective activities. 3-O-Methyldopa can be used in the research of nervous system diseases such as depression and Parkinson's disease.
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- Pureza: 99.55%
- No. CAS: 300-48-1
- Fòrmula: C10H13NO4
- Peso molecular:211.22
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
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Publications Citing Use of MedChemExpress (MCE) 3-O-Methyldopa
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Actividad biológica
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IL-6 |
IL-1β |
3-O-Methyldopa (10-100 μM; 24 h) significantly reduces the number of mesencephalic dopaminergic neurons in primary cultured mesencephalic neurons[1].
3-O-Methyldopa (10-100 μM; 24 h) inhibits the protective effect of L-DOPA (HY-N0304) on dopaminergic neurons in the mixed culture of mesencephalic neurons and striatal astrocytes[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Mice with chronic social defeat stress (CSDS) depression[2]
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Dosage:3 mg/kg
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Administration:Intraperitoneal injection; 10 days
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Result:Significantly improve depressive-like behaviors.
Significantly increased the sucrose preference of mice, shortened the immobility time in the forced swim test and tail suspension test, and increased the center distance in the open field test.
Reversed the increased levels of IL-1β and IL-6 in the hippocampus of CSDS mice.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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No. CAS 300-48-1
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Appearance Solid
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Peso molecular 211.22
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Fòrmula C10H13NO4
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Color White to light yellow
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SMILES
N[C@@H](CC1=CC=C(O)C(OC)=C1)C(O)=O
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Synonyms
3-Methoxy-L-tyrosine; 3-O-Methyl-L-DOPA
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Structure Classification
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Initial Source
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (1)
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Journal Impact Factor
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Most Recent
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Ann Med
2024 Dec;56(1):2417179. PMID: 39421970
Solvente y solubilidad
H2O : 10 mg/mL (47.34 mM; ultrasonic and warming and heat to 60°C)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 10 mg/mL (47.34 mM); Clear solution; Need ultrasonic
Pureza y Documentación
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Ficha de datos (274 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Masato Asanuma, et al. 3-O-Methyldopa inhibits astrocyte-mediated dopaminergic neuroprotective effects of L-DOPA. BMC Neurosci. 2016 Jul 25;17(1):52. [Content Brief]
[2]. Zhong Q, et al. Limosilactobacillus-related 3-OMDP as a potential therapeutic target for depression. Ann Med. 2024 Dec;56(1):2417179. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 4.7345 mL | 23.6723 mL | 47.3447 mL | 118.3617 mL |
| 5 mM | 0.9469 mL | 4.7345 mL | 9.4689 mL | 23.6723 mL | |
| 10 mM | 0.4734 mL | 2.3672 mL | 4.7345 mL | 11.8362 mL | |
| 15 mM | 0.3156 mL | 1.5782 mL | 3.1563 mL | 7.8908 mL | |
| 20 mM | 0.2367 mL | 1.1836 mL | 2.3672 mL | 5.9181 mL | |
| 25 mM | 0.1894 mL | 0.9469 mL | 1.8938 mL | 4.7345 mL | |
| 30 mM | 0.1578 mL | 0.7891 mL | 1.5782 mL | 3.9454 mL | |
| 40 mM | 0.1184 mL | 0.5918 mL | 1.1836 mL | 2.9590 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
3-O-Methyldopa Related Classifications
HY-113468A Related Classifications
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