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Referencia número: HY-182304

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CLR01 sodium

CLR01 sodium is a blood-brain barrier-permeable anti-aggregation agent. CLR01 sodium inhibits the de novo aggregation of Amyloid-β 40/42, α-synuclein, IAPP, tau protein and SOD1. CLR01 sodium reduces amyloid plaque burden in the cortex of triple-transgenic mice and improves the memory and motor abilities of these mice. CLR01 sodium can be used in research related to Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS).

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No. CAS: 1338489-62-5
Fòrmula: C₄₂H₃₀Na₂O₈P₂
Peso molecular:770.61

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

CLR01 sodium Chemical Structure

No. CAS: 1338489-62-5

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Descripciòn

Ver todos los productos específicos de isoformas α-synuclein :

In Vitro

CLR01 binds the N-terminal lysine of the KLVFF peptide with a K_d of 10 μM in PBS buffer^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

CLR01 (40 μg/kg; daily) reduces cortical plaque load and improves memory and mobility in triply transgenic Alzheimer's disease mice when administered at 40 μg/kg daily^[1].
CLR01 significantly reduces misfolded SOD1 in the spinal cord of G93A-SOD1 ALS mice but does not improve motor function in this fast-progressing model^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

No. CAS 1338489-62-5
Peso molecular 770.61
Fòrmula C₄₂H₃₀Na₂O₈P₂
SMILES

O=P(O)(O[Na])OC1=C2C([C@]3([H])C[C@@]2([H])C4=CC([C@]5([H])C6=CC=CC=C6[C@@]7([H])C5)=C7C=C43)=C(C8=C1[C@@]9([H])C%10=CC([C@@]%11([H])C%12=CC=CC=C%12[C@]%13([H])C%11)=C%13C=C%10[C@]8([H])C9)OP(O)(O[Na])=O
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Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Instrucciones de manejo (2659 KB)

Referencias

[1]. Hadrovic I, et al. Molecular Lysine Tweezers Counteract Aberrant Protein Aggregation. Front Chem. 2019;7:657. Published 2019 Oct 1. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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CLR01 sodium

Ver todos los productos específicos de isoformas α-synuclein

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Referencias

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CLR01 sodium Related Classifications

HY-182304 Related Classifications