IKZF2 - IKAROS family zinc finger 2 Gene

Also Known as ANF1A2; HELIOS; ZNF1A2; ZNFN1A2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 22807

About IKZF2

Cytogenetic location: 2q34 Genomic coordinates (GRCh38): 2:212,999,698-213,152,456 (from NCBI)

This gene has 14 transcripts (splice variants), 210 orthologues and 11 paralogues. Broad expression in esophagus (RPKM 4.7), urinary bladder (RPKM 3.1) and 21 other tissues.

Summary

This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This protein forms homo- or hetero-dimers with Other Ikaros family members, and is thought to function predominantly in early hematopoietic development. Multiple transcript variants encoding different isoforms have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008]

IKZF2 Products (7)

mRNA Protein Name
NM_001079526.2 NP_001072994.1 zinc finger protein Helios isoform 2
NM_001371274.1 NP_001358203.1 zinc finger protein Helios isoform 1
NM_001371275.1 NP_001358204.1 zinc finger protein Helios isoform 2
NM_001371276.1 NP_001358205.1 zinc finger protein Helios isoform 2
NM_001371277.1 NP_001358206.1 zinc finger protein Helios isoform 3
NM_001387220.1 NP_001374149.1 zinc finger protein Helios isoform 1
NM_016260.3 NP_057344.2 zinc finger protein Helios isoform 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence Referencias Source
enables protein binding IPI
IPI: Inferred from physical interaction
23088713 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IKZF2 Protein Structure

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (127 - 150)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (154 - 177)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (183 - 206)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 526 a.a.
Protein Preferred Names Protein Names

zinc finger protein Helios

  • ikaros family zinc finger protein 2

IKZF2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Referencias
Intra
IKZF2 Q9UKS7 CTBP2 Homo sapiens P56545-3
Y2H Prey Pooling
25416956
Intra
IKZF2 Q9UKS7 CTBP2 Homo sapiens P56545-3
Y2H Array
25416956
Intra
IKZF2 Q9UKS7 LONRF1 Homo sapiens Q17RB8
Y2H Prey Pooling
25416956
Intra
IKZF2 Q9UKS7 LONRF1 Homo sapiens Q17RB8
Validated Y2H
25416956
Cross
IKZF2 Q9UKS7 Hoxa1 Mus musculus P09022
Y2H
23088713
Cross
IKZF2 Q9UKS7 Hoxa1 Mus musculus P09022
Pull Down
23088713
Intra
IKZF2 Q9UKS7 CTBP2 Homo sapiens P56545
Y2H Array
25416956
Intra
IKZF2 Q9UKS7 AQP1 Homo sapiens P29972
Y2H Array
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
T-Cell Acute Lymphoblastic Leukemia

  • T-Cell Leukemia

  • Acute T Cell Leukemia

  • Precursor T Lymphoblastic Leukemia

  • Precursor T-Lymphoblastic Lymphoma/Leukemia

  • T Acute Lymphoblastic Leukemia

  • T-Cell Acute Lymphocytic Leukaemia

  • T-Cell Lymphoblastic Leukemia/Lymphoma

  • Leukemia T-Cell

  • Leukemia, T-Cell

  • Leukemia, Acute, Lymphoblastic, T-Cell

  • Leukemia, T-Cell Acute Lymphoblastic

  • Leukemia, Acute T-Cell

  • Precursor T-Cell Lymphoblastic Leukemia-Lymphoma

  • Precursor T-Cell Lymphoblastic Lymphoma

  • Precursor T Cell Lymphoblastic Leukemia/Lymphoblastic Lymphoma
Dermatitis, Atopic, 7

  • ATOD7

  • Dermatitis, Atopic, Susceptibility To, 7

  • Atopic Dermatitis 7

  • Dermatitis, Atopic 7
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (3)
Referencia número Nombre del producto Efecto
Pureza Phase
HY-173630 BMS-986449 Inhibitor / Phase 2
HY-182467 BMS-986482 Degrader / Phase 2
HY-145776 ALV1 Inhibitor 98.62% Phase 1

Pre-clinical Phase

Bioactive Molecules (24)
Referencia número Nombre del producto
Efecto
Pureza
Rare Diseases
HY-144998 NVP-DKY709 Inhibitor 99.66% Unkown
HY-157334 DEG-77 99.03% Unkown
HY-W1135319 SB-405483 99.33% Unkown
HY-159647 PLX-4545 96.76% Unkown
HY-159647A (S,S)-PLX-4545 Degrader / Unkown
HY-172931 DEG-35 Degrader 98.88% Unkown
HY-168615 MGD-28 Degrader 99.73% Unkown
HY-173630A (Rac)-BMS-986449 Inhibitor 99.05% Unkown
HY-172930 PVTX-405 97.07% Unkown
HY-159647B (1S,2S,3R)-PLX-4545 Degrader 91.78% Unkown
HY-168614 MGD-4 Degrader / Unkown
HY-182467A BMS-986482 acetate / Unkown
HY-RS06666 IKZF2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-172882 IKZF2-degrader 1 Degrader / Unkown
HY-172930B (R)-PVTX-405 Degrader / Unkown
HY-177754 IKZF2-degrader 3 Degrader / Unkown
HY-182799 IBA-12 Degrader / Unkown
HY-182807 CRBN ligand-899 / Unkown
HY-182808 E3 Ligase Ligand-linker Conjugate 230 / Unkown
HY-182945 IKZF2-degrader 5 / Unkown
HY-W1128213 IKZF2-degrader 2 Degrader / Unkown
HY-185300 IKZF2-degrader 4 Degrader / Unkown
HY-RS20037 Ikzf2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26540 Ikzf2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus IKZF2 RGD RGD:1308686
Felis catus IKZF2 VGNC VGNC:80245
Canis familiaris IKZF2 VGNC VGNC:41924
Macaca mulatta IKZF2 VGNC VGNC:73586
Bos taurus IKZF2 VGNC VGNC:56125
Mus musculus IKZF2 MGD MGI:1342541
Others IKZF2 NCBI