Meclizine
Based on 5 publication(s) in Google Scholar
Meclizine (Meclozine), an antihistamine, reversibly inhibits the interaction of histamine at the H1 receptors. Meclizine is a member of the piperazine class of H1 antagonists. Meclizine is an effective anti-motion sickness agent. Meclizine crosses the blood–brain barrier. Meclizine is an agonist ligand for mouse constitutive androstane receptor (CAR) and an inverse agonist for Human CAR. Meclizine can be used for the research of polyQ toxicity disorders, such as Huntington's disease.
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- No. CAS: 569-65-3
- Fòrmula: C25H27ClN2
- Peso molecular:390.95
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Almacenamiento:
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Publications Citing Use of MedChemExpress (MCE) Meclizine
MoreVer todos los productos específicos de isoformas Histamine Receptor
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Actividad biológica
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H1 Receptor |
Meclizine (Meclozine; 50 μM; 24 hours) significantly increases cell survival in STHdh
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:The murine striatal cells expressing wild-type (STHdhQ7/7) or mutant (STHdhQ111/111) huntingtin protein
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Concentration:50 µM
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Incubation Time:24 hours
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Result:Significantly increased cell survival in STHdhQ111/111 cells at 24 h after the removal of serum.
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Cell Line:Mutant (STHdhQ111/111) and wild-type (STHdhQ7/7) striatal cells
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Concentration:50 µM
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Incubation Time:0, 4, 10, 24 hours
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Result:Suppressed apoptosis, based on caspase 3 and 7 cleavage.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:8-10 wk old male C57BL/6 mice[4]
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Dosage:10, 30, 60 or 100 mg/kg
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Administration:Administered intraperitoneally
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Result:Protected mice from kidney ischemia-reperfusion injury.
Chemical Information
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No. CAS 569-65-3
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Peso molecular 390.95
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Fòrmula C25H27ClN2
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SMILES
CC1=CC(CN2CCN(C(C3=CC=C(Cl)C=C3)C4=CC=CC=C4)CC2)=CC=C1
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Synonyms
Meclozine
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (5)
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Journal Impact Factor
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Most Recent
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Phytomedicine
Ergothioneine alleviates hepatic steatosis by modulating PCYT2 to restore the phosphatidylethanolamine-ACOT8 homeostasis. [Abstract]2026 Aug:158:158238. PMID: 42275877 -
Am J Obstet Gynecol
Meclizine Improves Endometrial Repair and Reduces Simulated Menstrual Bleeding in Mice with Induced Adenomyosis. [Abstract]2024 Jul;231(1):113.e1-113.e13. PMID: 38367751 -
Ren Fail
2023 Dec;45(1):2230318. PMID: 37427767 -
J Biochem Mol Toxicol
Dihydroartemisinin Suppresses LOXL2-Mediated Glycerophospholipid Metabolic Reprogramming to Induce Cuproptosis in Colorectal Cancer Cells. [Abstract]2025 Aug;39(8):e70420. PMID: 40746272 -
Diabet Med
Wnt inhibitory factor 1 inhibits glycolysis through the HIF1α/PFKFB3 signalling pathway to regulate macrophage polarization and alleviate diabetic retinopathy. [Abstract]2026 May;43(5):e70285. PMID: 41814504
Pureza y Documentación
Referencias
[1]. Priti N. Patel, et al. Safety and Efficacy in the Treatment and Prevention of Motion Sickness.
[2]. Vishal M Gohil, et al. Meclizine is neuroprotective in models of Huntington's disease. Hum Mol Genet. 2011 Jan 15;20(2):294-300. [Content Brief]
[3]. Wendong Huang, et al. Meclizine Is an Agonist Ligand for Mouse Constitutive Androstane Receptor (CAR) and an Inverse Agonist for Human CAR [Content Brief]
[4]. Seiji Kishi, et al. Meclizine Preconditioning Protects the Kidney Against Ischemia-Reperfusion Injury. EBioMedicine. 2015 Jul 29;2(9):1090-101. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Meclizine Related Classifications
HY-B0349A Related Classifications
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