2. Protein Tyrosine Kinase/RTK PROTAC
  3. FAK PROTACs
  4. FC-11

FC-11 is a PROTAC FAK degrader (DC90: 1 nM) . FC-11 contains CRBN ligand Pomalidomide (HY-10984), linker and FAK ligand PF562271 (HY-10459).

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FC-11

FC-11 Estructura química

No. CAS : 2271035-37-9

Tamaño Precio Stock Cantidad
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 En stock
Solution
10 mM * 1 mL in DMSO En stock
Solid
1 mg En stock
5 mg En stock
10 mg En stock
25 mg En stock
50 mg En stock
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200 mg   Obtener un presupuesto  
500 mg   Obtener un presupuesto  

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Revisión del cliente

Based on 1 publication(s) in Google Scholar

FC-11 Related Antibodies

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Descripciòn

FC-11 is a PROTAC FAK degrader (DC90: 1 nM) . FC-11 contains CRBN ligand Pomalidomide (HY-10984), linker and FAK ligand PF562271 (HY-10459)[1].

In Vitro

FC-11 degrades FAK in various cell types, with DC50s being: 310 pM in TM3, 80 pM in PA1, 330 pM in MDA-MB-436, 370 pM in LNCaP, and 40 pM in Ramos[1].
FC-11 (1-10 nM, 8 h) degrades FAK in PA1 cells (compared to DMSO protein degradation) by 99%[1].
FC-11 (1-100 nM, 8 h) induces FAK degradation in PA1 through a CRBN-mediated and proteasome-dependent mechanism[1].
FC-11 (1-3000 nM, 0-9 h) inhibits FAK autophosphorylation in TM3 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

FC-11 Related Antibodies

Western Blot Analysis[1]

Cell Line: PA1
Concentration: 1, 10, 100 nM
Incubation Time: 8 h
Result: Degraded FAK protein.

Western Blot Analysis[1]

Cell Line: TM3
Concentration: 1, 10, 100, 1000, 3000 nM; 100 nM
Incubation Time: 8 h; 0.5, 1, 3, 6, 9 h
Result: Reduced FAK autophosphorylation.
Peso molecular

949.91

Fòrmula

C41H42F3N13O9S
No. CAS
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(C1=CN(CCOCCOCCNC2=CC=CC(C(N3C4C(NC(CC4)=O)=O)=O)=C2C3=O)N=N1)NC5=CC=C(NC6=NC=C(C(F)(F)F)C(NCC7=CC=CN=C7N(S(=O)(C)=O)C)=N6)C=C5
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvente y solubilidad
In Vitro: 

DMSO : 66.67 mg/mL (70.19 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.0527 mL 5.2637 mL 10.5273 mL
5 mM 0.2105 mL 1.0527 mL 2.1055 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Calculadora de molaridad

  • Calculadora de dilución

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Pureza y Documentación
Referencias

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.0527 mL 5.2637 mL 10.5273 mL 26.3183 mL
5 mM 0.2105 mL 1.0527 mL 2.1055 mL 5.2637 mL
10 mM 0.1053 mL 0.5264 mL 1.0527 mL 2.6318 mL
15 mM 0.0702 mL 0.3509 mL 0.7018 mL 1.7546 mL
20 mM 0.0526 mL 0.2632 mL 0.5264 mL 1.3159 mL
25 mM 0.0421 mL 0.2105 mL 0.4211 mL 1.0527 mL
30 mM 0.0351 mL 0.1755 mL 0.3509 mL 0.8773 mL
40 mM 0.0263 mL 0.1316 mL 0.2632 mL 0.6580 mL
50 mM 0.0211 mL 0.1053 mL 0.2105 mL 0.5264 mL
60 mM 0.0175 mL 0.0877 mL 0.1755 mL 0.4386 mL
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FC-11 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

FC-112271035-37-9FC11FC 11FAKPROTACsPTK2 protein tyrosine kinase 2PTK2Focal adhesion kinaseprotein degradationTM3MDA-MB-436PA1LNCaPRamosInhibitorinhibitorinhibit

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Nombre del producto:
FC-11
Cat. No.:
HY-139344
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