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Referencia número: HY-182002

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Apoptosis inducer 61

Apoptosis inducer 61 (Compound 4E) is an Apoptosis inducer. Apoptosis inducer 61 significantly downregulates the expression of BIRC3 and activates Apoptosis. Anticancer agent 313 exhibits anticancer activity against ER⁺ breast cancer cells, triple-negative breast cancer cells, and gastric cancer cells.

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Fòrmula: C₁₆H₁₂FN₇
Peso molecular:321.31

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Please store the product under the recommended conditions in the Certificate of Analysis.

Apoptosis inducer 61 Chemical Structure

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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Descripciòn

IC₅₀ & Target^[1]

BIRC3

Ver todos los productos específicos de isoformas IAP :

In Vitro

Apoptosis inducer 61 (1.56-200 μM; 48 h) potently inhibits the viability of MCF-7, MDA-MB-231 and HGC-27 cancer cells, with IC₅₀ values of 5.61 μM, 8.18 μM and 5.68 μM, respectively; this compound exhibits selective toxicity toward cancer cells compared to non-malignant CCD-1072Sk cells^[1].
Apoptosis inducer 61 (5.61 μM (MCF-7), 8.18 μM (MDA-MB-231); 48 h) induces apoptosis in MCF-7 and MDA-MB-231 breast cancer cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis^[1]

Cell Line:

MCF-7 breast cancer cells, MDA-MB-231 breast cancer cells
Concentration:

5.61 μM (MCF-7); 8.18 μM (MDA-MB-231)
Incubation Time:

48 h
Result:

Showed 12.35% apoptotic cells (8.73% early, 3.62% late) and 1.71% necrotic cells in MCF-7 cells.
Showed 9.78% apoptotic cells (5.54% early, 4.24% late) and 0.38% necrotic cells in MDA-MB-231 cells.

Chemical Information

Peso molecular 321.31
Fòrmula C₁₆H₁₂FN₇
SMILES

FC1=CC=C(C=C1)C2=CN(N=N2)CC3=NN(C=C3)C4=NC=NC=C4
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

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Instrucciones de manejo (2659 KB)

Referencias

[1]. Halac FA, et al. Triazole-substituted pyrazole-pyrimidine hybrids as anticancer agents: synthesis, cytotoxicity, apoptosis mechanisms, and JAB1-targeted structure-based design. Bioorg Chem. 2026;173:109633. [Content Brief]

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Apoptosis inducer 61

Ver todos los productos específicos de isoformas IAP

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Apoptosis inducer 61 Related Classifications

HY-182002 Related Classifications