BMS-751324
BMS-751324 is a p38α MAPK inhibitor. BMS-751324 equips a precursor of carbamyl-methyl linkage, containing esters and phosphate functional groups derived from hydroxyphenylacetic acid (HPA). BMS-751324 effectively inhibits foot swelling and LPS-induced TNFα production in an arthritic rat model.
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- No. CAS: 948842-66-8
- Fòrmula: C32H35N6O10P
- Peso molecular:694.63
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Chemical Information
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Help & FAQs
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Actividad biológica
BMS-751324 (10 μM; 0-60 min) can be hydrolyzed by alkaline phosphatase (human placental ALP), instead of esterase [1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
BMS-751324 (1 mg/kg-100 mg/kg for rat, 10 or 30 mg/kg for monkey with 5 mL/kg of methocel suspension; p.o.; single dose) exhibits a bio-conversion in animals[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 948842-66-8
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Peso molecular 694.63
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Fòrmula C32H35N6O10P
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SMILES
CC1=CC=C(C(NC2CC2)=O)C=C1NC3=NC=NN4C3=C(C)C(C(N(C(OCOC(CC5=CC=C(OP(O)(O)=O)C=C5)=O)=O)CCC)=O)=C4
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
BMS-751324 Related Classifications
HY-18759 Related Classifications
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