Desoxymansil
Desoxymansil is an anti-schistosomal agent. In mice, rabbits, dogs and monkeys, Desoxymansil undergoes oxidative metabolism via its isopropylaminomethyl side chain to produce a carboxylic acid metabolite, while this metabolic pathway is absent in rats. In rats, Desoxymansil undergoes α-carbon oxidation of the side chain to form an unstable aminomethanol that decomposes; the intermediate product is reduced to an alcohol metabolite, which is excreted in bile in the form of glucuronide. Desoxymansil can be used for the study of schistosomiasis.
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- No. CAS: 21738-41-0
- Fòrmula: C14H21N3O2
- Peso molecular:263.34
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
Desoxymansil (2.0 μmol; 30 min) is extensively hydroxylated to oxamniquine by liver microsomes from rat, mouse, and rabbit, with no detectable N-dealkylation of the isopropyl group[1].
Desoxymansil is converted to carboxylic acid metabolite V by whole liver homogenates from rabbit and mouse, while rat whole liver homogenates do not produce this metabolite[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Wistar rats (male, 250-300 g)[1]
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Dosage:15 mg/kg; 30 mg/kg
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Administration:i.p.; single dose
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Result:Excreted 28.5% of the total administered dose in bile as radioactivity, with 9.1% of the dose present as metabolite III and 4.0% as metabolite VI.
Excreted 14.7% of the total administered dose in bile as radioactivity, with 3.5% of the dose present as metabolite III and 2.8% as metabolite VI.
Detected no metabolite V in bile samples.
Chemical Information
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No. CAS 21738-41-0
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Peso molecular 263.34
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Fòrmula C14H21N3O2
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SMILES
CC(C)NCC1NC(C=C2[N+]([O-])=O)=C(C=C2C)CC1
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Desoxymansil Related Classifications
HY-183434 Related Classifications
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