ERDRP-0519
Based on 3 publication(s) in Google Scholar
ERDRP-0519, an orally bioavailable small-molecule Measles virus (MeV) polymerase inhibitor, prevents measles disease in squirrel monkeys (Saimiri sciureus). ERDRP-0519 inhibits morbilliviruses with nanomolar potency..
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- Pureza: 99.90%
- No. CAS: 1374006-96-8
- Fòrmula: C23H30F3N5O4S
- Peso molecular:529.58
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) ERDRP-0519
More
Actividad biológica
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Vero | CC50 |
>75 μM
Compound: 2o, ERDRP-00519
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Cytotoxicity against african green monkey Vero cells after 24 hrs by MTT assay
Cytotoxicity against african green monkey Vero cells after 24 hrs by MTT assay
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[PMID: 22480182] |
| Vero | EC50 |
0.06 μM
Compound: 2o, ERDRP-00519
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Antiviral activity against Measles virus Alaska infected african green monkey Vero cells expressing human SLAM assessed as decrease in viral titer at EC50 of cytopathic inhibition
Antiviral activity against Measles virus Alaska infected african green monkey Vero cells expressing human SLAM assessed as decrease in viral titer at EC50 of cytopathic inhibition
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[PMID: 22480182] |
| Vero | EC50 |
2.5 μM
Compound: 2o, ERDRP-00519
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Antiviral activity against Measles virus Alaska infected african green monkey Vero cells expressing human SLAM assessed as decrease in virus-induced cytopathic effect
Antiviral activity against Measles virus Alaska infected african green monkey Vero cells expressing human SLAM assessed as decrease in virus-induced cytopathic effect
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[PMID: 22480182] |
ERDRP-0519 exhibits potency against a panel of Measles virus (MeV) isolates with EC50s of 0.07- 0.3 μM[1]. ERDRP-0519 exhibits potency against MeV and related pathogens of the Morbillivirus genus, such as canine distemper virus (CDV)[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 1374006-96-8
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Appearance Solid
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Peso molecular 529.58
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Fòrmula C23H30F3N5O4S
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Color White to off-white
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SMILES
O=C(C1=CC(C(F)(F)F)=NN1C)NC2=CC=C(S(=O)(N3[C@H](CCN4CCOCC4)CCCC3)=O)C=C2
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (3)
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Journal Impact Factor
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Most Recent
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Cell
Differential inhibition of Morbillivirus and Henipavirus polymerases by ERDRP-0519 and structure-guided inhibitor optimization. [Abstract]2026 Apr 29:S0092-8674(26)00400-9. PMID: 42061399 -
Cell
Structures of the measles virus polymerase complex with non-nucleoside inhibitors and mechanism of inhibition. [Abstract]2025 Sep 4;188(18):4913-4923.e13. PMID: 40628260 -
Solvente y solubilidad
DMSO : 100 mg/mL (188.83 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (4.72 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (4.72 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureza y Documentación
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Ficha de datos (276 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Stefanie A Krumm, et al. An orally available, small-molecule polymerase inhibitor shows efficacy against a lethal morbillivirus infection in a large animal model. Sci Transl Med. 2014 Apr 16;6(232):232ra52. [Content Brief]
[2]. Richard K Plemper. Measles Resurgence and Drug Development. Curr Opin Virol. 2020 Apr;41:8-17. [Content Brief]
[3]. Kevin Wittwer, et al. Small-molecule polymerase inhibitor protects non-human primates from measles and reduces shedding. Nat Commun. 2021 Sep 2;12(1):5233. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.8883 mL | 9.4414 mL | 18.8829 mL | 47.2072 mL |
| 5 mM | 0.3777 mL | 1.8883 mL | 3.7766 mL | 9.4414 mL | |
| 10 mM | 0.1888 mL | 0.9441 mL | 1.8883 mL | 4.7207 mL | |
| 15 mM | 0.1259 mL | 0.6294 mL | 1.2589 mL | 3.1471 mL | |
| 20 mM | 0.0944 mL | 0.4721 mL | 0.9441 mL | 2.3604 mL | |
| 25 mM | 0.0755 mL | 0.3777 mL | 0.7553 mL | 1.8883 mL | |
| 30 mM | 0.0629 mL | 0.3147 mL | 0.6294 mL | 1.5736 mL | |
| 40 mM | 0.0472 mL | 0.2360 mL | 0.4721 mL | 1.1802 mL | |
| 50 mM | 0.0378 mL | 0.1888 mL | 0.3777 mL | 0.9441 mL | |
| 60 mM | 0.0315 mL | 0.1574 mL | 0.3147 mL | 0.7868 mL | |
| 80 mM | 0.0236 mL | 0.1180 mL | 0.2360 mL | 0.5901 mL | |
| 100 mM | 0.0189 mL | 0.0944 mL | 0.1888 mL | 0.4721 mL |
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