1374006-96-8
1374006-96-8
Chemical Structure
ERDRP-0519
- CAS No.: 1374006-96-8
- Formula:C23H30F3N5O4S
- Molecular Weight:529.58
IUPAC Name: (S)-1-methyl-N-(4-((2-(2-morpholinoethyl)piperidin-1-yl)sulfonyl)phenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide
InChIKey: JVZHTUQIMBYDSX-SFHVURJKSA-N
SMILES: O=C(C1=CC(C(F)(F)F)=NN1C)NC2=CC=C(S(=O)(N3[C@H](CCN4CCOCC4)CCCC3)=O)C=C2
Biological Activity: ERDRP-0519, an orally bioavailable small-molecule Measles virus (MeV) polymerase inhibitor, prevents measles disease in squirrel monkeys (Saimiri sciureus). ERDRP-0519 inhibits morbilliviruses with nanomolar potency.[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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ERDRP-0519 | 99.90% | ERDRP-0519, an orally bioavailable small-molecule Measles virus (MeV) polymerase inhibitor, prevents measles disease in squirrel monkeys (Saimiri sciureus). ERDRP-0519 inhibits morbilliviruses with nanomolar potency.. | ||||||||||||||||||||
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References
- [1]. Stefanie A Krumm, et al. An orally available, small-molecule polymerase inhibitor shows efficacy against a lethal morbillivirus infection in a large animal model. Sci Transl Med. 2014 Apr 16;6(232):232ra52. [Content Brief]
- [2]. Richard K Plemper. Measles Resurgence and Drug Development. Curr Opin Virol. 2020 Apr;41:8-17. [Content Brief]
- [3]. Kevin Wittwer, et al. Small-molecule polymerase inhibitor protects non-human primates from measles and reduces shedding. Nat Commun. 2021 Sep 2;12(1):5233. [Content Brief]
Keywords
