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ERDRP-0519 

Cat. No.: HY-102074
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ERDRP-0519, an orally bioavailable small-molecule Measles virus (MeV) polymerase inhibitor, prevents measles disease in squirrel monkeys (Saimiri sciureus). ERDRP-0519 inhibits morbilliviruses with nanomolar potency..

For research use only. We do not sell to patients.

ERDRP-0519 Chemical Structure

ERDRP-0519 Chemical Structure

CAS No. : 1374006-96-8

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Description

ERDRP-0519, an orally bioavailable small-molecule Measles virus (MeV) polymerase inhibitor, prevents measles disease in squirrel monkeys (Saimiri sciureus). ERDRP-0519 inhibits morbilliviruses with nanomolar potency.[1][2][3].

In Vitro

ERDRP-0519 exhibits potency against a panel of Measles virus (MeV) isolates with EC50s of 0.07- 0.3 µM[1]. ERDRP-0519 exhibits potency against MeV and related pathogens of the Morbillivirus genus, such as canine distemper virus (CDV)[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

A single-dose pharmacokinetic (PK) study is performed in squirrel monkeys by oral (intragastric) delivery of ERDRP-0519 (50 mg/kg) and blood sampling at seven predefined time points after dosing. Serum concentrations peak ~2 h post-administration (Cmax=3.27 µM)[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

529.58

Formula

C₂₃H₃₀F₃N₅O₄S

CAS No.
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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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ERDRP-0519
Cat. No.:
HY-102074
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