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Referencia número: HY-182799

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IBA-12

IBA-12 is a IKZF2 molecular glue/PROTAC degrader with a DC₅₀ of 276.2 nM (Jurkat cells) and 461.8 nM (Mino cells), and an IC₅₀ of 179.9 nM. IBA-12 binds to the canonical tryptophan triad pocket of CRBN to form a ternary complex with IKZF2. IBA-12 induces IKZF2 degradation mediated by the CRBN-dependent ubiquitin-proteasome system, with no effect on other CRBN substrates. IBA-12 induces the production of interleukin-2 (IL-2) through degrading IKZF2. IBA-12 is applicable to cancer immunology research.
(Pink: IZKF2 ligand (HY-Y1863); Blue: Cereblon ligand (HY-182807); Black: linker).

Para uso exclusivo en investigación. No vendemos a pacientes.

Fòrmula: C₂₄H₂₅ClN₄O₃
Peso molecular:452.93

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

IBA-12 Chemical Structure

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- IC₅₀ & Target
- In Vitro
- Parmacokinetics
Chemical Information
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Referencias
Calculators
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Bioz

Actividad biológica

Descripciòn

IBA-12 is a IKZF2 molecular glue/PROTAC degrader with a DC₅₀ of 276.2 nM (Jurkat cells) and 461.8 nM (Mino cells), and an IC₅₀ of 179.9 nM. IBA-12 binds to the canonical tryptophan triad pocket of CRBN to form a ternary complex with IKZF2. IBA-12 induces IKZF2 degradation mediated by the CRBN-dependent ubiquitin-proteasome system, with no effect on other CRBN substrates. IBA-12 induces the production of interleukin-2 (IL-2) through degrading IKZF2. IBA-12 is applicable to cancer immunology research^[1]. (Pink: IZKF2 ligand (HY-Y1863); Blue: Cereblon ligand (HY-182807); Black: linker).

IC₅₀ & Target^[1]

IKZF2

276.2 nM (DC₅₀)

Cereblon

Ver todos los productos específicos de isoformas PROTACs :

Ver todos los productos específicos de isoformas IKZF Family :

In Vitro

IBA-12 (0-1000 nM; 24 h) dose-dependently increases IL-2 production in stimulated Jurkat cells, confirming functional modulation of the IKZF2-regulated transcriptional pathway^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ELISA Assay^[1]

Cell Line:

stimulated Jurkat cells
Concentration:

0, 10, 100, 1000 and 1000 nM
Incubation Time:

24 h
Result:

Induced dose-dependent increases in IL-2 production.
Showed statistically significant increases observed at 100 and 1000 nM.

Parmacokinetics

Species	Dose	Route	T_1/2	T_max	C_max	AUC_0-t	MRT_0-∞	F	V_ss	CL
Rat^[1]	2 mg/kg	i.v.	2.68 h	0.194 h	1359 ng/mL	3748	2.39 h	/	1.27 L/kg	8.87 mL/min/kg
Rat^[1]	10 mg/kg	p.o.	2.49 h	0.667 h	2540 ng/mL	8339	2.57 h	44.5 %	/	/

Chemical Information

Peso molecular 452.93
Fòrmula C₂₄H₂₅ClN₄O₃
SMILES

O=C1CCC(N2NC(C=C(C3CCN(CC4=CC(Cl)=CC=C4)CC3)C=C5)=C5C2=O)C(N1)=O
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Instrucciones de manejo (2659 KB)

Referencias

[1]. Nie HJ, et al. Indazolone-Based Molecular Glue Degraders as a Tunable Platform for Reprogramming Cereblon Substrate Specificity. bioRxiv. 2026 Mar 17:2026-03.

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Actividad biológica
- Descripciòn
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureza y Documentación
Referencias

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IBA-12

Ver todos los productos específicos de isoformas PROTACs

Ver todos los productos específicos de isoformas IKZF Family

Actividad biológica

Chemical Information

Pureza y Documentación

Referencias

Calculators

Help & FAQs

IBA-12 Related Classifications

HY-182799 Related Classifications