JAK-IN-20
Based on 1 Customer Validation
JAK-IN-20 is a potent, pan and orally active JAK inhibitor with an IC50s of 7 nM, 5 nM, 14 nM for JAK1, JAK2, JAK3, respectively. JAK-IN-20 shows excellent pharmacokinetics and displays anti-inflammatory efficacy in vivo.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 99.63%
- No. CAS: 1654776-91-6
- Fòrmula: C28H30FN7O2
- Peso molecular:515.58
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Actividad biológica
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Chemical Information
- Pureza y Documentación
- Referencias
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Help & FAQs
Actividad biológica
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JAK1 7 nM (IC50) |
JAK2 5 nM (IC50) |
JAK3 14 nM (IC50) |
JAK-IN-20 (10 mg/kg; p.o.; once a day for 3 days) shows anti-inflammatory effect[1].
Pharmacokinetic Parameters of JAK-IN-20 in female Sprague Dawley rats[1].
| parameter | 32 |
| PO Dose (mg/kg) | 3 |
| Tmax (h) | 0.63(0.25-6) |
| Cmax (μg/mL) | 7.82±3.68 |
| AUC0-t (μg.h/mL) | 80.18±35.44 |
| T1/2,po (h) | 4.77±1.84 |
| MRT (h) | 7.54±2.52 |
| IV Dose (mg/kg) | 1 |
| C0 (μg/mL) | 4.70±2.50 |
| AUC0-t (μg.h/mL) | 18.89±1.76 |
| Vss (L/kg) | 0.32±0.14 |
| CL (mL/min/kg) | 0.85±0.13 |
| T1/2,iv (h) | 5.16±3.83 |
| MRT (h) | 6.69±4.03 |
| %F | 100 |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:7-10 weeks, 250-300g, male wistar rats[1]
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Dosage:
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Administration:3 mg/kg for p.o.; 1 mg/kg for i.v.
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Result:Showed fast oral absorption, higher plasma exposure, extended oral half-life and excellent oral bioavailability of 100%.
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Animal Model:Female Sprague Dawley rats ( PGPS rat model)[1]
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Dosage:10 mg/kg
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Administration:P.o.; once a day; 3 days
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Result:Showed anti-inflammatory effect.
Chemical Information
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No. CAS 1654776-91-6
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Appearance Solid
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Peso molecular 515.58
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Fòrmula C28H30FN7O2
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Color Light yellow to yellow
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SMILES
O=C(NCC#N)C1=CC=C(C2=NC(NC3=CC=C(N4CCC(N5CCOCC5)CC4)C=C3)=NC=C2F)C=C1
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Pureza y Documentación
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Ficha de datos (270 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
JAK-IN-20 Related Classifications
HY-143444 Related Classifications
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