1654776-91-6
1654776-91-6
Chemical Structure
JAK-IN-20
- CAS No.: 1654776-91-6
- Formula:C28H30FN7O2
- Molecular Weight:515.58
IUPAC Name: (9S,13S,14S,17S)-13-methyl-9,11,12,13,14,15,16,17-octahydro-6H-cyclopenta[a]phenanthrene-2,4,16,16-d4-3,17-diol
InChIKey: OJWUERASKIACOC-UHFFFAOYSA-N
SMILES: O=C(NCC#N)C1=CC=C(C2=NC(NC3=CC=C(N4CCC(N5CCOCC5)CC4)C=C3)=NC=C2F)C=C1
Biological Activity: JAK-IN-20 is a potent, pan and orally active JAK inhibitor with an IC50s of 7 nM, 5 nM, 14 nM for JAK1, JAK2, JAK3, respectively. JAK-IN-20 shows excellent pharmacokinetics and displays anti-inflammatory efficacy in vivo[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
JAK-IN-20 | 99.63% | JAK-IN-20 is a potent, pan and orally active JAK inhibitor with an IC50s of 7 nM, 5 nM, 14 nM for JAK1, JAK2, JAK3, respectively. JAK-IN-20 shows excellent pharmacokinetics and displays anti-inflammatory efficacy in vivo. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
References
Keywords
