Momelotinib-d4 dihydrochloride hydrate
Momelotinib-d4 (CYT387-d4) dihydrochloride hydrate is a deuterium labeled Momelotinib (HY-10961). Momelotinib (CYT387) is an ATP-competitive inhibitor of JAK1/JAK2 with IC50s of 11 nM and 18 nM,respectively. CYT387 shows much less activity against JAK3.
For research use only. We do not sell to patients.
- CAS No.: 2056097-81-3
- Formula: C23H22D4Cl2N6O3
- Molecular Weight:509.42
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Application
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 2056097-81-3
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Unlabeled CAS 1841094-17-4
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Molecular Weight 509.42
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Formula C23H22D4Cl2N6O3
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SMILES
N#CCNC(C(C=C1)=CC=C1C2=NC(NC3=CC=C(N4C([2H])([2H])COCC4([2H])[2H])C=C3)=NC=C2)=O.Cl.O.Cl
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Synonyms
CYT387-d4 hydrochloride hydrate
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Momelotinib-d4 dihydrochloride hydrate Related Classifications
HY-10961S8 Related Classifications
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