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  3. TBK1/IKKε-IN-2

TBK1/IKKε-IN-2 

Cat. No.: HY-12453 Purity: 98.50%
Handling Instructions

TBK1/IKKε-IN-2 is a dual TBK1 and IKKε inhibitor.

For research use only. We do not sell to patients.

TBK1/IKKε-IN-2 Chemical Structure

TBK1/IKKε-IN-2 Chemical Structure

CAS No. : 1292310-49-6

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 462 In-stock
Estimated Time of Arrival: December 31
5 mg USD 420 In-stock
Estimated Time of Arrival: December 31
10 mg USD 600 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1800 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2520 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Description

TBK1/IKKε-IN-2 is a dual TBK1 and IKKε inhibitor.

IC50 & Target[1]

TBK1

0.6 nM (IC50, at 5 μM ATP)

IKKε

3.9 nM (IC50, at 10 μM ATP)

In Vitro

TBK1/IKKε-IN-2 (Cmpound #1) inhibits TBK1 biochemical function in Ulight kinase assay at 5 and 250 μM ATP concentration with IC50s of 0.6 and 2.6 nM, rsespectively. TBK1/IKKε-IN-2 inhibits IKKε biochemical function in Ulight kinase assay at 10 μM ATP with an IC50 of 3.9 nM. The IC50 of TBK1/IKKε-IN-2 in the Panc 02.13 proliferation assay is 5 μM[1].

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 21.5 mg/mL (46.99 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1857 mL 10.9285 mL 21.8570 mL
5 mM 0.4371 mL 2.1857 mL 4.3714 mL
10 mM 0.2186 mL 1.0928 mL 2.1857 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Cell Assay
[1]

Cell proliferation experiments are carried out in a 96-well format (6 replicates), Panc 02.13 cells are plated at a density of 2,000 to 5,000 cells per well. At 24 hours following cell seeding, the cells are treated with the tool inhibitor titrations (e.g., TBK1/IKKε-IN-2, 1 nM, 10 nM, 100 nM, 1 μM and 10 μM) for 4 days at 37°C and then assayed by using the ATP CellTiter-Glo luminescent cell viability assay[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
Molecular Weight

457.52

Formula

C₂₆H₂₇N₅O₃

CAS No.

1292310-49-6

SMILES

N#CC1=CC(C2=NC(NC3=CC=C(N4CCOCC4)C=C3)=NC=C2)=CC=C1OC5CCOCC5

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
TBK1/IKKε-IN-2
Cat. No.:
HY-12453
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TBK1/IKKε-IN-2

Cat. No.: HY-12453