1. NF-κB
  2. IKK
  3. GSK319347A

GSK319347A 

Cat. No.: HY-14682 Purity: 98.93%
Handling Instructions

GSK319347A is a dual inhibitor of TBK1 and IKKε with IC50s of 93 nM and 469 nM, respectively. GSK319347A also inhibits IKK2 with an IC50 of 790 nM.

For research use only. We do not sell to patients.

GSK319347A Chemical Structure

GSK319347A Chemical Structure

CAS No. : 862812-98-4

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 599 In-stock
Estimated Time of Arrival: December 31
1 mg USD 190 In-stock
Estimated Time of Arrival: December 31
5 mg USD 580 In-stock
Estimated Time of Arrival: December 31
10 mg   Get quote  
50 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

GSK319347A is a dual inhibitor of TBK1 and IKKε with IC50s of 93 nM and 469 nM, respectively. GSK319347A also inhibits IKK2 with an IC50 of 790 nM.

IC50 & Target[1][2]

TBK1

93 nM (IC50)

IKK-ε

469 nM (IC50)

IKK2

790 nM (IC50)

In Vitro

GSK319347A (Compound 1) inhibits TBK1 enzyme with an IC50 of 93 nM, which also translates into good cell potency (72 nM). Moreover, IKK-3 Inhibitor exhibits excellent selectivity against cell-cycle kinases CDK2 and AurB[1]. IKK-3 Inhibitor (Compound 13) is a novel IκB kinase 2 (IKK2) inhibitor with an IC50 of 790 nM[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

469.53

Formula

C₂₂H₁₉N₃O₅S₂

CAS No.

862812-98-4

SMILES

COC1=CC2=C(C=C1OC)N(C3=CC(OCC4=CC=CC=C4S(=O)(C)=O)=C(C#N)S3)C=N2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 45 mg/mL (95.84 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1298 mL 10.6489 mL 21.2979 mL
5 mM 0.4260 mL 2.1298 mL 4.2596 mL
10 mM 0.2130 mL 1.0649 mL 2.1298 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: 2.25 mg/mL (4.79 mM); Suspended solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.25 mg/mL (4.79 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 98.93%

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Keywords:

GSK319347AIKKIκB kinaseI kappa B kinaseInhibitorinhibitorinhibit

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Product Name:
GSK319347A
Cat. No.:
HY-14682
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